New technologies to assess genotype-phenotype relationships

The accelerating pace of the discovery of genes has far surpassed our capabilities to understand their biological function--in other words, the phenotypes they engender. We need efficient and comprehensive large-scale phenotyping technologies. This presents a difficult challenge because phenotypes a...

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Bibliographic Details
Published inNature reviews. Genetics Vol. 4; no. 4; pp. 309 - 314
Main Author Bochner, Barry R
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group 01.04.2003
Subjects
Biological and medical sciences
Biology
Classical genetics, quantitative genetics, hybrids
Escherichia coli - genetics
Fundamental and applied biological sciences. Psychology
Genes
Genetic Techniques
Genetics of eukaryotes. Biological and molecular evolution
Genomics
Genotype
Genotype & phenotype
Methods, theories and miscellaneous
Oligonucleotide Array Sequence Analysis
Phenotype
Saccharomyces cerevisiae - genetics
Yeast
Genotype
Phenotype
Method
Genomics
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Summary:The accelerating pace of the discovery of genes has far surpassed our capabilities to understand their biological function--in other words, the phenotypes they engender. We need efficient and comprehensive large-scale phenotyping technologies. This presents a difficult challenge because phenotypes are numerous and diverse, and they can be observed and annotated at the molecular, cellular and organismal level. New technologies and approaches will therefore be required. Here, I describe recent efforts to develop new and efficient technologies for assessing cellular phenotypes.
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ISSN:1471-0056
1471-0064
DOI:10.1038/nrg1046