Genome-Wide Estrogen Receptor Activity in Breast Cancer

• Published in: Endocrinology (Philadelphia) Vol. 162; no. 2; p. 1
• Main Authors: Farcas, Anca M, Nagarajan, Sankari, Cosulich, Sabina, Carroll, Jason S
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.02.2021
• Subjects: Adaptability; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Cancer; Chromatin; Development and progression; Disease Progression; Endocrinology; Enhancer Elements, Genetic; Estrogen; Estrogen receptors; Estrogens; Fulvestrant; Gene Expression Regulation, Neoplastic; Genetic aspects; Genomics; Humans; Mini-Reviews; Phenols; Receptors; Receptors, Estrogen - metabolism; Regulatory sequences; Therapeutic applications; Transcription Factors - metabolism; United Kingdom; Breast cancer; enhancers; chromatin; cofactors; estrogen receptor
• ISSN: 0013-7227; 1945-7170
• DOI: 10.1210/endocr/bqaa224

Abstract The largest subtype of breast cancer is characterized by the expression and activity of the estrogen receptor alpha (ERalpha/ER). Although several effective therapies have significantly improved survival, the adaptability of cancer cells means that patients frequently stop responding or develop resistance to endocrine treatment. ER does not function in isolation and multiple associating factors have been reported to play a role in regulating the estrogen-driven transcriptional program. This review focuses on the dynamic interplay between some of these factors which co-occupy ER-bound regulatory elements, their contribution to estrogen signaling, and their possible therapeutic applications. Furthermore, the review illustrates how some ER association partners can influence and reprogram the genomic distribution of the estrogen receptor. As this dynamic ER activity enables cancer cell adaptability and impacts the clinical outcome, defining how this plasticity is determined is fundamental to our understanding of the mechanisms of disease progression.