Repeated Treatment with Furazolidone Induces Multiple Cytochrome P450-Related Activities in Chicken Liver, but Not in Rat Liver

• Published in: Journal of Veterinary Medical Science Vol. 75; no. 11; pp. 1497 - 1502
• Main Authors: SASAKI, Nobuo, MATUMOTO, Tomoyuki, IKENAKA, Yoshinori, NAKAYAMA, Shouta M. M., ISHIZUKA, Mayumi, KAZUSAKA, Akio, FUJITA, Shoichi
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.11.2013; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Animals; antimicrobial substance; Blotting, Western - veterinary; chicken; Chickens - metabolism; Cytochrome P-450 CYP1A1 - analysis; Cytochrome P-450 CYP2B1 - analysis; Cytochrome P-450 Enzyme System - analysis; Cytochrome P-450 Enzyme System - metabolism; cytochrome P450; drug metabolism; Female; Furazolidone - administration & dosage; Furazolidone - pharmacology; Hydrazines - administration & dosage; Hydrazines - pharmacology; Liver - enzymology; Liver - metabolism; Microsomes, Liver - enzymology; Microsomes, Liver - metabolism; Oxazolidinones - administration & dosage; Oxazolidinones - pharmacology; Rats; Rats, Wistar; Sleep - drug effects; Toxicology
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.12-0531

The nitrofuran antimicrobial agent, furazolidone (FZ), is still used in veterinary medicine in some countries in the Middle and Far Eastern countries. The present study aimed to investigate the effects of successive bolus doses of FZ and its metabolite 3-amino-2-oxazolidinone (AOZ) on cytochrome P450 (CYP)-related activities in the livers of rats and chickens. Female Wistar rats and white Leghorn chickens were orally administered FZ once a day for 4 consecutive days. FZ-treated chickens showed an increase in multiple CYP-related activities, however, rats treated with FZ did not show these changes. In chickens, treatment with FZ also induced production of microsomal CYP2C6-like apoprotein. The present study demonstrated that FZ caused a multiple-type induction of CYP-related activities in chickens, but not in rats.