Circadian gene variants in cancer

Humans as diurnal beings are active during the day and rest at night. This daily oscillation of behavior and physiology is driven by an endogenous circadian clock not environmental cues. In modern societies, changes in lifestyle have led to a frequent disruption of the endogenous circadian homeostas...

Full description

Saved in:
Bibliographic Details
Published inAnnals of medicine (Helsinki) Vol. 46; no. 4; p. 208
Main Authors Kettner, Nicole M, Katchy, Chinenye A, Fu, Loning
Format Journal Article
LanguageEnglish
Published England 01.06.2014
Subjects
Animals
Circadian Clocks - genetics
Circadian Clocks - physiology
Circadian Rhythm - genetics
Circadian Rhythm - physiology
Genetic Variation
Homeostasis - physiology
Humans
Mutation
Neoplasms - genetics
Neoplasms - pathology
Risk Factors
tumor suppression
social jet lag
cellular senescence
molecular clock
DNA damage response
cell cycle
circadian rhythm
Aging
metabolism
cancer risk factors
Online AccessGet more information

Cover

More Information
Summary:Humans as diurnal beings are active during the day and rest at night. This daily oscillation of behavior and physiology is driven by an endogenous circadian clock not environmental cues. In modern societies, changes in lifestyle have led to a frequent disruption of the endogenous circadian homeostasis leading to increased risk of various diseases including cancer. The clock is operated by the feedback loops of circadian genes and controls daily physiology by coupling cell proliferation and metabolism, DNA damage repair, and apoptosis in peripheral tissues with physical activity, energy homeostasis, immune and neuroendocrine functions at the organismal level. Recent studies have revealed that defects in circadian genes due to targeted gene ablation in animal models or single nucleotide polymorphism, deletion, deregulation and/or epigenetic silencing in humans are closely associated with increased risk of cancer. In addition, disruption of circadian rhythm can disrupt the molecular clock in peripheral tissues in the absence of circadian gene mutations. Circadian disruption has recently been recognized as an independent cancer risk factor. Further study of the mechanism of clock-controlled tumor suppression will have a significant impact on human health by improving the efficiencies of cancer prevention and treatment.
ISSN:1365-2060
DOI:10.3109/07853890.2014.914808