Controlled release of amoxicillin from bacterial cellulose membranes

• Published in: Central European journal of chemistry Vol. 12; no. 9; pp. 962 - 967
• Main Authors: Pavaloiu, Ramona-Daniela, Stoica, Anicuta, Stroescu, Marta, Dobre, Tanase
• Format: Journal Article
• Language: English
• Published: Heidelberg Versita 01.09.2014; De Gruyter
• Subjects: Amoxicillin; Bacteria; Bacterial cellulose; Biochemistry; Biological and Medical Physics; Biophysics; Box-Behnken Design; Cellulose; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Controlled release; Drug delivery systems; Drug release; Drugs; Geochemistry; Independent variables; Membranes; Riccce 18; Drug release; Bacterial cellulose; Box-Behnken Design
• ISSN: 1895-1066; 2391-5420; 1644-3624; 2391-5420
• DOI: 10.2478/s11532-014-0541-3

Bacterial cellulose (BC), a natural polymer with unique physical and mechanical properties, has several applications in the biomedical field, including drug loading and controlled drug delivery. For this study, a Box-Behnken experimental design was employed as a statistical tool to optimize the release of a model drug, amoxicillin, from BC membranes. Independent variables studied were the concentration of the drug (X 1 ), the concentration of glycerol (X 2 ) and the concentration of a permeation enhancer (X 3 ). From the variables studied, drug concentration had the highest effect on drug release. Among the other independent variables, th linear and quadratic X 2 terms, the linear X 3 term and the interaction term X 2 X 3 were found to affect the release of amoxicillin from bacterial cellulose membranes.