Fluorine-substituted hydroxyapatite scaffolds hydrothermally grown from aragonitic cuttlefish bones

• Published in: Acta biomaterialia Vol. 3; no. 2; pp. 243 - 249
• Main Authors: Kannan, S., Rocha, J.H.G., Agathopoulos, S., Ferreira, J.M.F.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2007
• Subjects: Animals; Apatites - chemistry; Aragonite; Biocompatible Materials; Bone and Bones - metabolism; Calcium Carbonate - chemistry; Crystallization; Cuttlefish bone; Decapodiformes; Durapatite - chemistry; Fluorapatite; Fluorine - pharmacology; Hydrothermal transformation; Kinetics; Materials Testing; Models, Chemical; Scaffolds; Spectroscopy, Fourier Transform Infrared; Time Factors; X-Ray Diffraction; Aragonite; Hydrothermal transformation; Cuttlefish bone; Scaffolds; Fluorapatite
• ISSN: 1742-7061; 1878-7568
• DOI: 10.1016/j.actbio.2006.09.006

Porous hydroxyapatite scaffolds with different levels of fluorine substitution (46% and 85%) on the OH sites were produced via hydrothermal transformation of aragonitic cuttlefish bones at 200 °C and calcination at temperatures up to 1200 °C. The increasing level of F substitution reduces the kinetics and probably the yield of the reaction. The incorporation of F in the lattice of hydroxypatite caused a lowering of the unit cell volume due to reduction of the length of the a-axis. The crystallites formed were close in size to bone-like apatite and were orientated along the a-axis rather than the c-axis. There was evidence of AB-type carbonated apatite.