Denoising approach with deep learning-based reconstruction for neuromelanin-sensitive MRI: image quality and diagnostic performance

• Published in: Japanese journal of radiology Vol. 41; no. 11; pp. 1216 - 1225
• Main Authors: Oshima, Sonoko, Fushimi, Yasutaka, Miyake, Kanae Kawai, Nakajima, Satoshi, Sakata, Akihiko, Okuchi, Sachi, Hinoda, Takuya, Otani, Sayo, Numamoto, Hitomi, Fujimoto, Koji, Shima, Atsushi, Nambu, Masahito, Sawamoto, Nobukatsu, Takahashi, Ryosuke, Ueno, Kentaro, Saga, Tsuneo, Nakamoto, Yuji
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.11.2023; Springer Nature B.V
• Subjects: Deep learning; Diagnostic systems; Image acquisition; Image contrast; Image degradation; Image processing; Image quality; Image reconstruction; Imaging; Locus coeruleus; Magnetic resonance imaging; Medical imaging; Medicine; Medicine & Public Health; Movement disorders; Neurodegenerative diseases; Noise reduction; Nuclear Medicine; Original; Original Article; Parkinson's disease; Quality assessment; Radiology; Radiotherapy; Signal to noise ratio; Substantia nigra; Deep learning; Magnetic resonance imaging; Neuromelanin; Parkinson’s disease; Denoising
• ISSN: 1867-1071; 1867-108X
• DOI: 10.1007/s11604-023-01452-9

Purpose Neuromelanin-sensitive MRI (NM-MRI) has proven useful for diagnosing Parkinson’s disease (PD) by showing reduced signals in the substantia nigra (SN) and locus coeruleus (LC), but requires a long scan time. The aim of this study was to assess the image quality and diagnostic performance of NM-MRI with a shortened scan time using a denoising approach with deep learning-based reconstruction (dDLR). Materials and methods We enrolled 22 healthy volunteers, 22 non-PD patients and 22 patients with PD who underwent NM-MRI, and performed manual ROI-based analysis. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) in ten healthy volunteers were compared among images with a number of excitations (NEX) of 1 (NEX1), NEX1 images with dDLR (NEX1 + dDLR) and 5-NEX images (NEX5). Acquisition times for NEX1 and NEX5 were 3 min 12 s and 15 min 58 s, respectively. Diagnostic performances using the contrast ratio (CR) of the SN (CR_SN) and LC (CR_LC) and those by visual assessment for differentiating PD from non-PD were also compared between NEX1 and NEX1 + dDLR. Results Image quality analyses revealed that SNRs and CNRs of the SN and LC in NEX1 + dDLR were significantly higher than in NEX1, and comparable to those in NEX5. In diagnostic performance analysis, areas under the receiver operating characteristic curve (AUC) using CR_SN and CR_LC of NEX1 + dDLR were 0.87 and 0.75, respectively, which had no significant difference with those of NEX1. Visual assessment showed improvement of diagnostic performance by applying dDLR. Conclusion Image quality for NEX1 + dDLR was comparable to that of NEX5. dDLR has the potential to reduce scan time of NM-MRI without degrading image quality. Both 1-NEX NM-MRI with and without dDLR showed high AUCs for diagnosing PD by CR. The results of visual assessment suggest advantages of dDLR. Further tuning of dDLR would be expected to provide clinical merits in diagnosing PD.