Evaluation of Eight Plasma Proteins as Candidate Blood-Based Biomarkers for Malignant Gliomas

• Published in: Cancer investigation Vol. 32; no. 8; pp. 423 - 429
• Main Authors: Lange, Ryan P., Everett, Allen, Dulloor, Pratima, Korley, Frederick K., Bettegowda, Chetan, Blair, Cherie, Grossman, Stuart A., Holdhoff, Matthias
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 14.09.2014; Taylor & Francis
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - blood; Blood Proteins - metabolism; Brain Neoplasms - blood; Brain Tumors; Cancer Biomarkers; Child; Child, Preschool; Circulating Biomarkers; Female; Glioma; Glioma - blood; Humans; Male; Middle Aged; Proteins; Young Adult; Proteins; Cancer Biomarkers; Brain Tumors; Glioma; Circulating Biomarkers
• ISSN: 0735-7907; 1532-4192
• DOI: 10.3109/07357907.2014.933237

Eight brain-derived proteins were evaluated regarding their potential for further development as a blood-based biomarker for malignant gliomas. Plasma levels for glial fibrillary acidic protein, neurogranin, brain-derived neurotrophic factor, intracellular adhesion molecule 5, metallothionein-3, beta-synuclein, S100 and neuron specific enolase were tested in plasma of 23 patients with high-grade gliomas (WHO grade IV), 11 low-grade gliomas (WHO grade II), and 15 healthy subjects. Compared to the healthy controls, none of the proteins appeared to be specific for glioblastomas. However, the data are suggestive of higher protein levels in gliosarcomas (n = 2), which may deserve further exploration.