Social outcomes and quality of life of childhood cancer survivors in Japan: a cross-sectional study on marriage, education, employment and health-related QOL (SF-36)

• Published in: International journal of hematology Vol. 93; no. 5; pp. 633 - 644
• Main Authors: Ishida, Yasushi, Honda, Misato, Kamibeppu, Kiyoko, Ozono, Shuichi, Okamura, Jun, Asami, Keiko, Maeda, Naoko, Sakamoto, Naoko, Inada, Hiroko, Iwai, Tsuyako, Kakee, Naoko, Horibe, Keizo
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.05.2011; Springer; Springer Nature B.V
• Subjects: Adult; Biological and medical sciences; Cross-Sectional Studies; Disease-Free Survival; Educational Status; Employment - psychology; Female; Hematologic and hematopoietic diseases; Hematology; Humans; Income - statistics & numerical data; Japan - epidemiology; Male; Marriage - psychology; Medical sciences; Medicine; Medicine & Public Health; Neoplasms - ethnology; Neoplasms - psychology; Neoplasms - radiotherapy; Odds Ratio; Oncology; Original Article; Outcome Assessment (Health Care) - statistics & numerical data; Quality of Life - psychology; Research Design; Siblings - ethnology; Siblings - psychology; Social Perception; Stem Cell Transplantation - ethnology; Stem Cell Transplantation - psychology; Surveys and Questionnaires; Survivors - psychology; Young Adult; Asia; Japan; Childhood cancer survivors; Education; Employment; Marriage; Health-related QOL; SF-36; Human; Prognosis; Hematology; Health; Survivor; Malignant tumor; Health education; Quality of life; Cross sectional study; Child; Social aspect; Cancer
• ISSN: 0925-5710; 1865-3774
• DOI: 10.1007/s12185-011-0843-6

Social outcomes and quality of life (QOL) of childhood cancer survivors (CCSs) remain unknown in Japan. We investigated these outcomes in young adult CCSs compared to those of their siblings in Japan, and analyzed the association between social outcome and SF-36 health survey subscale scores. Between 2007 and 2009, we performed a cross-sectional survey using self-rating questionnaires. We estimated social outcomes and health-related QOL by performing the SF-36 in each group: CCSs with or without stem cell transplantation (SCT)/radiotherapy (RT) and their siblings. Adjusted odds ratios for outcomes of interest were estimated using logistic regression analysis. Questionnaires from 185 CCSs and 72 CCS’s siblings were analyzed. There were no differences in educational attainment or annual income. The SF-36 subscale scores of CCSs with SCT and RT were significantly lower than those of siblings in physical functioning (PF) ( p < 0.001 and 0.003, respectively) and general health (GH) (both p = 0.001). Lower PF scores correlated with recurrence ( p = 0.041) and late effects ( p = 0.010), and poor GH scores with late effects ( p = 0.006). The CCSs had made efforts to attain educational/vocational goals; however, a significant proportion of CCSs who had experienced late effects remain at increased risk of experiencing diminished QOL.