Assessment of Clinical Characteristics and Mortality-Associated Factors in COVID-19 Critical Cases in Kuwait

• Published in: Medical principles and practice Vol. 30; no. 2; pp. 185 - 192
• Main Authors: Ayed, Mariam, Borahmah, Abdulwahab A., Yazdani, Anwar, Sultan, Ahmad, Mossad, Ahmad, Rawdhan, Hanouf
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.04.2021
• Subjects: Adult; Bacterial infections; Coronaviruses; COVID-19; COVID-19 - mortality; Female; Hospital Mortality; Humans; Intensive Care Units; Kuwait - epidemiology; Male; Middle Aged; Mortality; Original Paper; Pandemics; Pneumonia, Viral - mortality; Pneumonia, Viral - virology; Retrospective Studies; Risk Factors; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Kuwait; Acute respiratory distress syndrome; SARS-CoV-2; Pneumonia; Coronavirus infection
• ISSN: 1011-7571; 1423-0151; 1423-0151
• DOI: 10.1159/000513047

Objective: The objective of this study was to assess the clinical characteristics and identify mortality risk factors in intensive care unit (ICU)-admitted COVID-19 patients. Methods: We recruited and analyzed SARS-CoV-2-infected adult patients (age ≥18 years) who were admitted to the ICU at Jaber Al-Ahmad Al Sabah Hospital, Kuwait, between March 1, 2020, and April 30, 2020. The risk factors associated with in-hospital mortality were assessed using multiple regression analysis. Results: We recruited a total of 103 ICU patients in this retrospective cohort. The median age of the patients was 53 years and the fatality rate was 45.6%; majority (85.5%) were males and 37% patients had more than 2 comorbidities. Preexisting hypertension, moderate/severe acute respiratory distress syndrome, lymphocyte count <0.5 × 10 9 , serum albumin <22 g/L, procalcitonin >0.2 ng/mL, D-dimer >1,200 ng/mL, and the need for continuous renal replacement therapy were significantly associated with mortality. Conclusion: This study describes the clinical characteristics and risk factors for mortality among ICU patients with CO­VID-19. Early identification of risk factors for mortality might help improve outcomes.