Targeting Dystroglycan in the Brain

The dystrophin-glycoprotein complex is a multisubunit complex that connects the extracellular matrix components to the cytoskeletal matrix of muscle fiber cells and is required for muscle integrity. Mutations in this complex are associated with muscular dystrophy. Although the role of dystroglycan h...

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Bibliographic Details
Published inNeuron Vol. 37; no. 2; pp. 193 - 196
Main Authors Montanaro, F., Carbonetto, S.
Format Book Review Journal Article
LanguageEnglish
Published United States Elsevier Inc 23.01.2003
Elsevier Limited
Subjects
Animals
Basement Membrane - metabolism
Brain Chemistry - physiology
Cell Movement - physiology
Cytoskeletal Proteins - metabolism
Cytoskeletal Proteins - physiology
Dystroglycans
Genes
Humans
Kinases
Membrane Glycoproteins - metabolism
Membrane Glycoproteins - physiology
Muscle, Skeletal - physiology
Muscular dystrophy
Muscular system
Mutation
Neurons - physiology
Rodents
Synaptic Transmission - physiology
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Summary:The dystrophin-glycoprotein complex is a multisubunit complex that connects the extracellular matrix components to the cytoskeletal matrix of muscle fiber cells and is required for muscle integrity. Mutations in this complex are associated with muscular dystrophy. Although the role of dystroglycan has been explored mainly in the context of muscle, recent work has also demonstrated a novel role for dystroglycan in the CNS and thus provides potential insights into the brain abnormalities associated with some forms of muscular dystrophy.
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ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(03)00032-1