Contribution of Sialic Acid-Binding Adhesin to Pathogenesis of Experimental Endocarditis Caused by Streptococcus gordonii DL1

An insertional mutation in hsa, the gene encoding the sialic acid-binding adhesin of Streptococcus gordonii DL1, resulted in a significant reduction of the infection rate of the organism and an inflammatory reaction in the rat aortic valve with experimental endocarditis, suggesting that the adhesin...

Full description

Saved in:
Bibliographic Details
Published inInfection and Immunity Vol. 74; no. 1; pp. 740 - 743
Main Authors Takahashi, Yukihiro, Takashima, Eizo, Shimazu, Kisaki, Yagishita, Hisao, Aoba, Takaaki, Konishi, Kiyoshi
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 2006
Subjects
Adhesins, Bacterial - physiology
Animals
Aortic Valve - microbiology
Aortic Valve - pathology
Bacterial Infections
Bacteriology
Biological and medical sciences
Endocarditis, Bacterial - metabolism
Fundamental and applied biological sciences. Psychology
Heart Valve Diseases - microbiology
Heart Valve Diseases - pathology
Microbiology
Miscellaneous
Rats
Streptococcal Infections - metabolism
Streptococcus - pathogenicity
Streptococcus gordonii
Sialic acid
Microbiology
Pathogenesis
Streptococcus gordonii
Cardiovascular disease
Immunity
Streptococcaceae
Heart disease
Endocardial disease
Endocarditis
Bacteria
Micrococcales
Adhesin
Online AccessGet full text

Cover

More Information
Summary:An insertional mutation in hsa, the gene encoding the sialic acid-binding adhesin of Streptococcus gordonii DL1, resulted in a significant reduction of the infection rate of the organism and an inflammatory reaction in the rat aortic valve with experimental endocarditis, suggesting that the adhesin contributes to the infectivity of the organism for heart valves.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Editor: V. J. DiRita
Corresponding author. Mailing address: Department of Microbiology, Nippon Dental University School of Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan. Phone: 81-3-3261-8763. Fax: 81-3-3264-8399. E-mail: biseibut@tky.ndu.ac.jp.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.74.1.740-743.2006