The Multifunctional Fungal Ergosterol

• Published in: mBio Vol. 9; no. 5
• Main Author: Rodrigues, Marcio L.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 18.09.2018
• Subjects: Antifungal Agents; Candida albicans; Ergosterol; fungi; Host-Microbe Biology; immunity; Macrophages; Microbial Sensitivity Tests; Pyroptosis; Saccharomyces cerevisiae; Candida albicans; antifungal agents; immunity; fungi; Saccharomyces cerevisiae; ergosterol

The roles of ergosterol in the regulation of membrane fluidity and structure, as well its role as a target for the activity of antifungals, have been known for decades. Two recent studies, however, demonstrated that ergosterol is an immunologically active lipid that induces pyroptosis and that virtu...