The Multifunctional Fungal Ergosterol

The roles of ergosterol in the regulation of membrane fluidity and structure, as well its role as a target for the activity of antifungals, have been known for decades. Two recent studies, however, demonstrated that ergosterol is an immunologically active lipid that induces pyroptosis and that virtu...

Full description

Saved in:
Bibliographic Details
Published inmBio Vol. 9; no. 5
Main Author Rodrigues, Marcio L.
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 18.09.2018
Subjects
Antifungal Agents
Candida albicans
Ergosterol
fungi
Host-Microbe Biology
immunity
Macrophages
Microbial Sensitivity Tests
Pyroptosis
Saccharomyces cerevisiae
Candida albicans
antifungal agents
immunity
fungi
Saccharomyces cerevisiae
ergosterol
Online AccessGet full text

Cover

More Information
Summary:The roles of ergosterol in the regulation of membrane fluidity and structure, as well its role as a target for the activity of antifungals, have been known for decades. Two recent studies, however, demonstrated that ergosterol is an immunologically active lipid that induces pyroptosis and that virtually all steps of its biosynthetic process are potential drug targets. The roles of ergosterol in the regulation of membrane fluidity and structure, as well its role as a target for the activity of antifungals, have been known for decades. Two recent studies, however, demonstrated that ergosterol is an immunologically active lipid that induces pyroptosis and that virtually all steps of its biosynthetic process are potential drug targets. In combination, those two reports strongly indicate that the biological relevance of ergosterol is broader than the current literature suggests.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Commentary-3
content type line 23
ISSN:2161-2129
2150-7511
2150-7511
DOI:10.1128/mBio.01755-18