Chromium(III) release from chromium‐tanned leather elicits allergic contact dermatitis: a use test study

• Published in: Contact dermatitis Vol. 78; no. 5; pp. 307 - 314
• Main Authors: Hedberg, Yolanda S., Erfani, Behnaz, Matura, Mihály, Lidén, Carola
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.2018; Wiley Subscription Services, Inc
• Subjects: allergic contact dermatitis; Chromium; Contact dermatitis; Dermatitis; Eczema; Hypersensitivity; Leather; Original; Skin; skin exposure assessment; use test; chromium; use test; allergic contact dermatitis; skin exposure assessment; leather
• ISSN: 0105-1873; 1600-0536; 1600-0536
• DOI: 10.1111/cod.12946

Summary Background Chromium (Cr) is a common skin sensitizer. The use of Cr(VI) in leather is restricted in the EU, but that of Cr(III) is not. Objectives To assess whether prolonged exposure to Cr‐tanned leather with mainly Cr(III) release may elicit allergic contact dermatitis in Cr‐allergic individuals. Method Ten Cr‐allergic subjects and 22 controls were patch tested with serial dilutions of Cr(III) and Cr(VI), and with leather samples. They then conducted a use test with a Cr‐tanned and a Cr‐free leather bracelet over a period of 3 weeks, for 12 h per day. Cr deposited on the skin from the bracelets was measured in the controls, and the diphenylcarbazide test for Cr(VI) and extraction tests for Cr(III) and Cr(VI) were conducted for the different leathers. Results Four of 10 Cr‐allergic subjects developed positive reactions to the Cr‐tanned bracelet within 7–21 days, whereas only 1 of 10 had a positive patch test reaction to this leather. Cr released from the Cr‐tanned leather was most probably entirely Cr(III), with a quantifiable amount being deposited on the skin. Conclusions This study strongly suggests that prolonged and repeated exposure to Cr‐tanned leather with mainly Cr(III) release is capable of eliciting allergic contact dermatitis in Cr‐allergic individuals.