Soluble class 1 antigens (sHLA) in CSF and serum of patients with HIV infection
sHLA are secreted by B and T lymphocytes upon activation. These antigens are present in serum and cerebrospinal fluid (CSF). The establishment of a sHLA index, IH = (CSF sHLA/serum sHLA)/(CSF albumin/serum albumin) helped us to define that values above 9.7 reflect an intrathecal synthesis of these p...
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| Published in | Acta neurologica Scandinavica Vol. 82; no. 1; p. 14 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Denmark
01.07.1990
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| Subjects | |
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| Abstract | sHLA are secreted by B and T lymphocytes upon activation. These antigens are present in serum and cerebrospinal fluid (CSF). The establishment of a sHLA index, IH = (CSF sHLA/serum sHLA)/(CSF albumin/serum albumin) helped us to define that values above 9.7 reflect an intrathecal synthesis of these proteins. IH was significantly increased in a group of patients with intrathecal production of IgG against HIV-1 (HIV) and directly correlated with the synthesis of such antibodies. Therefore, IH seems to be an index of lymphocyte activation in CNS. |
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| AbstractList | sHLA are secreted by B and T lymphocytes upon activation. These antigens are present in serum and cerebrospinal fluid (CSF). The establishment of a sHLA index, IH = (CSF sHLA/serum sHLA)/(CSF albumin/serum albumin) helped us to define that values above 9.7 reflect an intrathecal synthesis of these proteins. IH was significantly increased in a group of patients with intrathecal production of IgG against HIV-1 (HIV) and directly correlated with the synthesis of such antibodies. Therefore, IH seems to be an index of lymphocyte activation in CNS. |
| Author | Villar, L M Gonzalez-Porque, P Alvarez-Cermeño, J C Bootello, A Casado, C Varela, J M Ferreira, A Najera, R Dominguez, M |
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| Snippet | sHLA are secreted by B and T lymphocytes upon activation. These antigens are present in serum and cerebrospinal fluid (CSF). The establishment of a sHLA index,... |
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| SubjectTerms | Histocompatibility Antigens Class I - analysis Histocompatibility Antigens Class I - blood Histocompatibility Antigens Class I - cerebrospinal fluid HIV Infections - blood HIV Infections - cerebrospinal fluid HIV Infections - immunology Humans Solubility |
| Title | Soluble class 1 antigens (sHLA) in CSF and serum of patients with HIV infection |
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