Soluble class 1 antigens (sHLA) in CSF and serum of patients with HIV infection

• Published in: Acta neurologica Scandinavica Vol. 82; no. 1; p. 14
• Main Authors: Alvarez-Cermeño, J C, Casado, C, Villar, L M, Ferreira, A, Varela, J M, Dominguez, M, Bootello, A, Najera, R, Gonzalez-Porque, P
• Format: Journal Article
• Language: English
• Published: Denmark 01.07.1990
• Subjects: Histocompatibility Antigens Class I - analysis; Histocompatibility Antigens Class I - blood; Histocompatibility Antigens Class I - cerebrospinal fluid; HIV Infections - blood; HIV Infections - cerebrospinal fluid; HIV Infections - immunology; Humans; Solubility
• ISSN: 0001-6314
• DOI: 10.1111/j.1600-0404.1990.tb01580.x

sHLA are secreted by B and T lymphocytes upon activation. These antigens are present in serum and cerebrospinal fluid (CSF). The establishment of a sHLA index, IH = (CSF sHLA/serum sHLA)/(CSF albumin/serum albumin) helped us to define that values above 9.7 reflect an intrathecal synthesis of these proteins. IH was significantly increased in a group of patients with intrathecal production of IgG against HIV-1 (HIV) and directly correlated with the synthesis of such antibodies. Therefore, IH seems to be an index of lymphocyte activation in CNS.