Importance of Detecting Multidrug Resistance Proteins in Acute Leukemia Prognosis and Therapy

• Published in: Journal of clinical laboratory analysis Vol. 27; no. 1; pp. 62 - 71
• Main Authors: de Moraes, Ana Carolina Rabello, Maranho, Caroline Klein, Rauber, Gabriela Schneider, Santos-Silva, Maria Cláudia
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.01.2013; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: ABCB1; ABCC1; Acute Disease; acute leukemia; ATP Binding Cassette Transporter, Sub-Family B - analysis; ATP Binding Cassette Transporter, Sub-Family B - metabolism; ATP-Binding Cassette, Sub-Family B, Member 1 - analysis; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Cell Line, Tumor; Chemotherapy; Drug resistance; Humans; Leukemia; Leukemia - metabolism; Leukemia - pathology; LRP; Models, Biological; multidrug resistance; Multidrug Resistance-Associated Proteins - analysis; Multidrug Resistance-Associated Proteins - metabolism; Prognosis; Proteins; Vault Ribonucleoprotein Particles - analysis; Vault Ribonucleoprotein Particles - metabolism
• ISSN: 0887-8013; 1098-2825
• DOI: 10.1002/jcla.21563

Multidrug resistance (MDR) is a multifactorial phenomenon and the role of these proteins in generating the MDR phenotype is controversial. With this in mind, this review compiled the current data on the role of ABCB1, ABCC1, and LRP proteins in the prognosis of hematologic neoplasms and their influence on the choice of therapy. Literature showed that the detection of these proteins, mainly ABCB1, is important in the AL prognosis. However, there is controversy regarding the methodology used for their detection. In summary, the expression and activity profiles of ABCB1, ABCC1, and LRP, proteins capable of promoting the efflux of a variety of chemotherapeutic agents from the cell cytoplasm represent one of the greatest causes of failure in AL treatment. J. Clin. Lab. Anal. 27:62–71, 2013. © 2012 Wiley Periodicals, Inc.