Effects of three nasal topical steroids in the intraocular pressure compartment

• Published in: Otolaryngology-head and neck surgery Vol. 130; no. 2; p. 187
• Main Authors: Bross-Soriano, Daniel, Hanenberg-Milver, Carlos, Schimelmitz-Idi, Jose, Arrieta-Gomez, Jose R, Astorga del Toro, Rigoberto, Bravo-Escobar, Gerardo
• Format: Journal Article
• Language: English
• Published: England 01.02.2004
• Subjects: Adolescent; Adult; Androstadienes - pharmacology; Androstadienes - therapeutic use; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Beclomethasone - pharmacology; Beclomethasone - therapeutic use; Double-Blind Method; Fluticasone; Glucocorticoids - pharmacology; Glucocorticoids - therapeutic use; Humans; Intraocular Pressure - drug effects; Middle Aged; Mometasone Furoate; Pregnadienediols - pharmacology; Pregnadienediols - therapeutic use; Prospective Studies; Rhinitis - drug therapy
• ISSN: 0194-5998
• DOI: 10.1016/j.otohns.2003.09.020

The purpose of this study was to evaluate whether the use of fluticasone propionate, mometasone furoate, or beclomethasone dipropionate for the treatment of rhinitis produced, as a side effect, an increase in the intraocular pressure; only one printed article proclaims that the increase of secondary intraocular pressure is due to the use of local nasal steroids. We conducted a comparative, double-blind, experimental, prospective, longitudinal study in which 360 patients were divided at random into 4 groups; 90 of them were given a placebo (control group) and the other 270 were divided into 3 other groups of 90 patients each and given a different local nasal steroid for each group. Measurement parameters All patients had their intraocular pressure measured by Goldman's tonometry at 3 weeks, 6 weeks, 3 months, 6 months, and 1 year after using the placebo or local nasal steroid. Variations were found in the intraocular pressure of patients who used local steroid, with discreet elevations in the beclomethasone dipropionate and mometasone furoate groups; however, variations were always within normal limits. Fluticasone propionate, mometasone furoate, and beclomethasone dipropionate cause variations in the intraocular pressure, but the variations are within normal limits.