Long Noncoding RNAs and MicroRNAs in Cardiovascular Pathophysiology

RNAs not encoding proteins have gained prominence over the last couple of decades as fundamental regulators of cellular function. Not surprisingly, their dysregulation is increasingly being linked to pathology. Here, we review recent reports investigating the pathophysiological relevance of this spe...

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Bibliographic Details
Published inCirculation research Vol. 116; no. 4; pp. 751 - 762
Main Authors Thum, Thomas, Condorelli, Gianluigi
Format Journal Article
LanguageEnglish
Published United States American Heart Association, Inc 13.02.2015
Subjects
Animals
Cardiovascular Diseases - genetics
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - physiopathology
Cardiovascular System - metabolism
Cardiovascular System - physiopathology
Gene Expression Regulation
Genetic Predisposition to Disease
Humans
MicroRNAs - metabolism
Phenotype
RNA, Long Noncoding - metabolism
Signal Transduction
lncRNAs
microRNAs
cardiac remodelling
heart failure
cardiac hypertrophy
myocardial infarction
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Summary:RNAs not encoding proteins have gained prominence over the last couple of decades as fundamental regulators of cellular function. Not surprisingly, their dysregulation is increasingly being linked to pathology. Here, we review recent reports investigating the pathophysiological relevance of this species of RNA for the cardiovascular system, concentrating mainly on recent findings on long noncoding RNAs and microRNAs in cardiac hypertrophy and failure.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0009-7330
1524-4571
DOI:10.1161/CIRCRESAHA.116.303549