PKM2 released by neutrophils at wound site facilitates early wound healing by promoting angiogenesis

Neutrophils infiltration/activation following wound induction marks the early inflammatory response in wound repair. However, the role of the infiltrated/activated neutrophils in tissue regeneration/proliferation during wound repair is not well understood. Here, we report that infiltrated/activated...

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Published inWound repair and regeneration Vol. 24; no. 2; pp. 328 - 336
Main Authors Zhang, Yinwei, Li, Liangwei, Liu, Yuan, Liu, Zhi-Ren
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.03.2016
Subjects
Animals
Cell Proliferation
Disease Models, Animal
Extracellular Matrix - pathology
Immunohistochemistry
Inflammation - enzymology
Inflammation - pathology
Mice
Mice, Inbred C57BL
Neovascularization, Physiologic
Neutrophils - enzymology
Neutrophils - secretion
Pyruvate Kinase - secretion
Wound Healing - physiology
Wounds and Injuries - enzymology
Wounds and Injuries - pathology
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Summary:Neutrophils infiltration/activation following wound induction marks the early inflammatory response in wound repair. However, the role of the infiltrated/activated neutrophils in tissue regeneration/proliferation during wound repair is not well understood. Here, we report that infiltrated/activated neutrophils at wound site release pyruvate kinase M2 (PKM2) by its secretive mechanisms during early stages of wound repair. The released extracellular PKM2 facilitates early wound healing by promoting angiogenesis at wound site. Our studies reveal a new and important molecular linker between the early inflammatory response and proliferation phase in tissue repair process.
Bibliography:ArticleID:WRR12411
istex:C639EE76000F3D4F11306BE55F1B95BCF98D6D1B
ark:/67375/WNG-CRMLR1WS-D
National Institute of Health - No. CA175112, CA118113
Georgia Cancer Coalition to Z.R. Liu
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1067-1927
1524-475X
DOI:10.1111/wrr.12411