Stereotactic Biopsy of Cerebral Lesions in AIDS
Stereotactic brain biopsy was used to establish diagnoses of conditions in patients with AIDS. Two hundred fifty stereotactic biopsies and one open resection were performed for 243 patients. Pathologically abnormal tissue was obtained in 246 (98%) of the procedures, and 16 patients (6%) had >1 di...
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Published in | Clinical infectious diseases Vol. 30; no. 3; pp. 491 - 499 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Chicago, IL
The University of Chicago Press
01.03.2000
University of Chicago Press |
Subjects | |
Online Access | Get full text |
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Summary: | Stereotactic brain biopsy was used to establish diagnoses of conditions in patients with AIDS. Two hundred fifty stereotactic biopsies and one open resection were performed for 243 patients. Pathologically abnormal tissue was obtained in 246 (98%) of the procedures, and 16 patients (6%) had >1 diagnosis. Diagnoses included lymphoma in 82 (33%), progressive multifocal leukoencephalopathy in 73 (30%), and tumors not ordinarily associated with AIDS in 7 (3%). In one-third of the cases, the tissue diagnosis differed from the predicted diagnosis. Four of the first 32 patients (12%) developed intracranial bleeding hours after surgery, which was fatal in 3 (9%). Subsequently, all patients were treated with a coagulopathy protocol that included preoperative and postoperative administration of coagulation factors, and there were no further instances of delayed bleeding in the 218 subsequent patients. Among those later patients, there were 7 complications (3%), leading to 4 deaths (2%), a complication rate that compares favorably with that among patients without AIDS. |
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Bibliography: | istex:4436B30A524966045091F388A8EFBA4D25F8F5C8 ark:/67375/HXZ-P08CGKW7-V ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 1058-4838 1537-6591 |
DOI: | 10.1086/313685 |