Vascular Permeability Factor/Vascular Endothelial Growth Factor in Nasal Polyps

• Published in: Acta oto-laryngologica Vol. 120; no. 543; pp. 170 - 174
• Main Author: I. Vento, C. H. J. Wolff, P. J. Salven, M. L. Hytönen, L. O. Ertama, C. H. O. Malmberg, S.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Basingstoke Informa UK Ltd 2000; Taylor & Francis; Taylor and Francis
• Subjects: Adolescent; Adult; Aged; Antibodies, Monoclonal - immunology; Biological and medical sciences; Capillary Permeability - physiology; Endothelial Growth Factors - metabolism; Endothelium, Vascular - metabolism; Endothelium, Vascular - pathology; Female; Humans; Immunohistochemistry; Lymphokines - metabolism; Male; Mast Cells - metabolism; Medical sciences; Middle Aged; Nasal Polyps - immunology; Nasal Polyps - metabolism; Nasal Polyps - pathology; Otorhinolaryngology. Stomatology; Transforming Growth Factors - metabolism; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Human; Nose disease; Healthy subject; Cytokine; Etiopathogenesis; Permeability factor; Vascular endothelium growth factor; Polypeptide; Nose; Blood vessel; ENT disease; Benign neoplasm; Comparative study; Growth factor; Polyp
• ISSN: 0001-6489; 0365-5237; 1651-2251; 1651-2464
• DOI: 10.1080/000164800454314

Although the aetiology of polyps is still, for the most part, unknown, the disease is known to involve tissue oedema. Vascular permeability/vascular endothelial growth factor (VPF/VEGF) is a major inducer of angiogenesis and capillary permeability. This study investigated VPF/VEGF expression in biopsies of nasal polyps from 39 patients and in healthy nasal mucosa from 10 patients by immunohistochemical staining. Staining for VPF/VEGF in the mucosal surface and in the glandular epithelium of nasal polyps was weaker than in normal controls. In two patients, strong staining for VPF/VEGF was found in a granular pattern in mast cells, while the mast cells in other polyposis patients appeared to be largely degranulated. VPF/VEGF was not seen in the mast cells of control patients. Although expression of VPF/VEGF was not increased in the epithelium of the nasal polyps, VPF/VEGF secreted from mast cells may take part in nasal polyp formation.