Neuraminidase-1 (NEU1): Biological Roles and Therapeutic Relevance in Human Disease

• Published in: Current Issues in Molecular Biology Vol. 46; no. 8; pp. 8031 - 8052
• Main Authors: Du, Jingxia, Shui, Hanqi, Chen, Rongjun, Dong, Yibo, Xiao, Chengyao, Hu, Yue, Wong, Nai-Kei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.08.2024; MDPI
• Subjects: Amino acids; Cardiovascular diseases; Development and progression; disease mechanisms; drug development; Gene therapy; lysosomal sialidase; Medical research; Medicine, Experimental; Muscles; Nervous system diseases; neuraminidase-1; Proteins; Review; sialic acids (SAs); drug development; lysosomal sialidase; neuraminidase-1; disease mechanisms; sialic acids (SAs)

Neuraminidases catalyze the desialylation of cell-surface glycoconjugates and play crucial roles in the development and function of tissues and organs. In both physiological and pathophysiological contexts, neuraminidases mediate diverse biological activities via the catalytic hydrolysis of terminal...