Polymethoxylated flavonoids in citrus fruits: absorption, metabolism, and anticancer mechanisms against breast cancer

• Published in: PeerJ (San Francisco, CA) Vol. 11; p. e16711
• Main Authors: Wang, Yiyu, Mou, Yuan, Lu, Senlin, Xia, Yuhua, Cheng, Bo
• Format: Journal Article
• Language: English
• Published: United States PeerJ. Ltd 03.01.2024; PeerJ, Inc; PeerJ Inc
• Subjects: Absorption and metabolism; Anti-breast cancer; Antitumor activity; Bioavailability; Biosynthesis; Breast cancer; Cancer; Carcinogens; Care and treatment; Cell cycle; Citrus; Citrus fruits; Cytochrome P-450; Demethylation; Enzymes; Estrogen; Estrogens; Flavonoids; Flavonoids - pharmacology; Fruit; Hydroxylation; Isoflavones; Keywords; Ligands; Metabolism; Metabolites; Methylation; Molecular mechanism; Neoplasms; Oncology, Experimental; Physiological aspects; Polymethoxylated flavonoids; Prevention; Steroids; Toxicity; Tumors; Absorption and metabolism; Anti-breast cancer; Polymethoxylated flavonoids; Molecular mechanism

Polymethoxylated flavonoids (PMFs) are a subclass of flavonoids found in citrus fruits that have shown multifunctional biological activities and potential anticancer effects against breast cancer. We studied the absorption, metabolism, species source, toxicity, anti-cancer mechanisms, and molecular...