Polymethoxylated flavonoids in citrus fruits: absorption, metabolism, and anticancer mechanisms against breast cancer

Polymethoxylated flavonoids (PMFs) are a subclass of flavonoids found in citrus fruits that have shown multifunctional biological activities and potential anticancer effects against breast cancer. We studied the absorption, metabolism, species source, toxicity, anti-cancer mechanisms, and molecular...

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Published inPeerJ (San Francisco, CA) Vol. 11; p. e16711
Main Authors Wang, Yiyu, Mou, Yuan, Lu, Senlin, Xia, Yuhua, Cheng, Bo
Format Journal Article
LanguageEnglish
Published United States PeerJ. Ltd 03.01.2024
PeerJ, Inc
PeerJ Inc
Subjects
Absorption and metabolism
Anti-breast cancer
Antitumor activity
Bioavailability
Biosynthesis
Breast cancer
Cancer
Carcinogens
Care and treatment
Cell cycle
Citrus
Citrus fruits
Cytochrome P-450
Demethylation
Enzymes
Estrogen
Estrogens
Flavonoids
Flavonoids - pharmacology
Fruit
Hydroxylation
Isoflavones
Keywords
Ligands
Metabolism
Metabolites
Methylation
Molecular mechanism
Neoplasms
Oncology, Experimental
Physiological aspects
Polymethoxylated flavonoids
Prevention
Steroids
Toxicity
Tumors
Absorption and metabolism
Anti-breast cancer
Polymethoxylated flavonoids
Molecular mechanism
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Abstract Polymethoxylated flavonoids (PMFs) are a subclass of flavonoids found in citrus fruits that have shown multifunctional biological activities and potential anticancer effects against breast cancer. We studied the absorption, metabolism, species source, toxicity, anti-cancer mechanisms, and molecular targets of PMFs to better utilize their anticancer activity against breast cancer. We discuss the absorption and metabolism of PMFs in the body, including the methylation, demethylation, and hydroxylation processes. The anticancer mechanisms of PMFs against breast cancer were also reviewed, including the estrogen activity, cytochrome P-450 enzyme system, and arylhydrocarbon receptor (AhR) inhibition, along with various molecular targets and potential anticancer effects. Although PMFs may be advantageous in the prevention and treatment for breast cancer, there is a lack of clinical evidence and data to support their efficacy. Despite their promise, there is still a long way to go before PMFs can be applied clinically.
AbstractList Polymethoxylated flavonoids (PMFs) are a subclass of flavonoids found in citrus fruits that have shown multifunctional biological activities and potential anticancer effects against breast cancer. We studied the absorption, metabolism, species source, toxicity, anti-cancer mechanisms, and molecular targets of PMFs to better utilize their anticancer activity against breast cancer. We discuss the absorption and metabolism of PMFs in the body, including the methylation, demethylation, and hydroxylation processes. The anticancer mechanisms of PMFs against breast cancer were also reviewed, including the estrogen activity, cytochrome P-450 enzyme system, and arylhydrocarbon receptor (AhR) inhibition, along with various molecular targets and potential anticancer effects. Although PMFs may be advantageous in the prevention and treatment for breast cancer, there is a lack of clinical evidence and data to support their efficacy. Despite their promise, there is still a long way to go before PMFs can be applied clinically.
Polymethoxylated flavonoids (PMFs) are a subclass of flavonoids found in citrus fruits that have shown multifunctional biological activities and potential anticancer effects against breast cancer. We studied the absorption, metabolism, species source, toxicity, anti-cancer mechanisms, and molecular targets of PMFs to better utilize their anticancer activity against breast cancer. We discuss the absorption and metabolism of PMFs in the body, including the methylation, demethylation, and hydroxylation processes. The anticancer mechanisms of PMFs against breast cancer were also reviewed, including the estrogen activity, cytochrome P-450 enzyme system, and arylhydrocarbon receptor (AhR) inhibition, along with various molecular targets and potential anticancer effects. Although PMFs may be advantageous in the prevention and treatment for breast cancer, there is a lack of clinical evidence and data to support their efficacy. Despite their promise, there is still a long way to go before PMFs can be applied clinically.Polymethoxylated flavonoids (PMFs) are a subclass of flavonoids found in citrus fruits that have shown multifunctional biological activities and potential anticancer effects against breast cancer. We studied the absorption, metabolism, species source, toxicity, anti-cancer mechanisms, and molecular targets of PMFs to better utilize their anticancer activity against breast cancer. We discuss the absorption and metabolism of PMFs in the body, including the methylation, demethylation, and hydroxylation processes. The anticancer mechanisms of PMFs against breast cancer were also reviewed, including the estrogen activity, cytochrome P-450 enzyme system, and arylhydrocarbon receptor (AhR) inhibition, along with various molecular targets and potential anticancer effects. Although PMFs may be advantageous in the prevention and treatment for breast cancer, there is a lack of clinical evidence and data to support their efficacy. Despite their promise, there is still a long way to go before PMFs can be applied clinically.
ArticleNumber e16711
Audience Academic
Author Xia, Yuhua
Mou, Yuan
Wang, Yiyu
Lu, Senlin
Cheng, Bo
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  organization: Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, Hubei, China
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  givenname: Yuan
  surname: Mou
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  organization: Department of General Surgery, People’s Hospital Affiliated to Chongqing Three Gorges Medical College, Wanzhou District, Chongqing, China
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  givenname: Senlin
  surname: Lu
  fullname: Lu, Senlin
  organization: Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, Hubei, China, Chong Qing Wan Zhou Health Center for Women and Children, Wanzhou, Chongqing, China
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  fullname: Xia, Yuhua
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  givenname: Bo
  surname: Cheng
  fullname: Cheng, Bo
  organization: Xinjiang Institute of Materia Medica, Key Lab of Xinjiang Uighur Medicine, Urumqi, Xinjiang, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38188169$$D View this record in MEDLINE/PubMed
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crossref_primary_10_1016_j_cclet_2024_110768
crossref_primary_10_1080_10408398_2024_2398636
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Anti-breast cancer
Polymethoxylated flavonoids
Molecular mechanism
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Snippet Polymethoxylated flavonoids (PMFs) are a subclass of flavonoids found in citrus fruits that have shown multifunctional biological activities and potential...
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StartPage e16711
SubjectTerms Absorption and metabolism
Anti-breast cancer
Antitumor activity
Bioavailability
Biosynthesis
Breast cancer
Cancer
Carcinogens
Care and treatment
Cell cycle
Citrus
Citrus fruits
Cytochrome P-450
Demethylation
Enzymes
Estrogen
Estrogens
Flavonoids
Flavonoids - pharmacology
Fruit
Hydroxylation
Isoflavones
Keywords
Ligands
Metabolism
Metabolites
Methylation
Molecular mechanism
Neoplasms
Oncology, Experimental
Physiological aspects
Polymethoxylated flavonoids
Prevention
Steroids
Toxicity
Tumors
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Title Polymethoxylated flavonoids in citrus fruits: absorption, metabolism, and anticancer mechanisms against breast cancer
URI https://www.ncbi.nlm.nih.gov/pubmed/38188169
https://www.proquest.com/docview/2909313544
https://www.proquest.com/docview/2911842513
https://doaj.org/article/ae242906327845189da3574c294c2d55
Volume 11
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