Carriage of Antibiotic-Resistant Pneumococci among Asian Children: A Multinational Surveillance by the Asian Network for Surveillance of Resistant Pathogens (ANSORP)

• Published in: Clinical infectious diseases Vol. 32; no. 10; pp. 1463 - 1469
• Main Authors: Lee, Nam Yong, Song, Jae-Hoon, Kim, Sungmin, Peck, Kyong Ran, Ahn, Kang-Mo, Lee, Sang-Il, Yang, Yonghong, Li, Jie, Chongthaleong, Anan, Tiengrim, Surapee, Aswapokee, Nalinee, Lin, Tzou-Yien, Wu, Jue-Lan, Chiu, Cheng-Hsun, Lalitha, M. K., Thomas, Kurien, Cherian, Thomas, Perera, Jennifer, Yee, Ti Teow, Jamal, Farida, Warsa, Usman Chatib, Van, Pham Hung, Carlos, Celia C., Shibl, Atef M., Jacobs, Michael R., Appelbaum, Peter C.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 15.05.2001; University of Chicago Press
• Subjects: Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimicrobials; Asia - epidemiology; Asians; Biological and medical sciences; Carrier State - epidemiology; Carrier State - microbiology; Child care; Child, Preschool; Children; Computer surveillance; Drug Resistance, Microbial; Electrophoresis, Gel, Pulsed-Field; Female; Humans; Infant; Major Article; Male; Medical sciences; Microbial Sensitivity Tests; Nasopharynx - microbiology; Pathogens; Penicillin; Penicillin Resistance - genetics; Pharmacology. Drug treatments; Pneumococcal Infections - epidemiology; Pneumococcal Infections - microbiology; Population Surveillance; Predisposing factors; Research universities; Serotyping; Streptococcus pneumoniae; Streptococcus pneumoniae - classification; Streptococcus pneumoniae - drug effects; Streptococcus pneumoniae - genetics; Tropical medicine; Vietnam; Asia; Sri Lanka; Taiwan; Korea; Human; Prevalence; Typing; Drug susceptibility test; Serogroup; Nasopharynx; Epidemiology; Streptococcus pneumoniae; Streptococcaceae; Antibiotic; Microbiological investigation; Minimum inhibitory concentration; Bacteria; Micrococcales; Serotype; Antibacterial agent; Sanitary surveillance; Child; Colonization; Comparative study
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/320165

To investigate the nasal carriage of antibiotic-resistant pneumococci by children, anterior nasal swabs were done for 4963 children <5 years old in 11 countries in Asia and the Middle East. In total, 1105 pneumococci isolates (carriage rate, 22.3%) were collected, 35.8% of which were found to be nonsusceptible to penicillin. Prevalence of penicillin nonsusceptibility was highest in Taiwan (91.3%), followed by Korea (85.8%), Sri Lanka (76.5%), and Vietnam (70.4%). Penicillin resistance was related to residence in urban areas, enrollment in day care, and a history of otitis media. The most common serogroups were 6 (21.5%), 23 (16.5%), and 19 (15.7%). The most common clone, as assessed by pulsed-field gel electrophoresis, was identical to the Spanish 23F clone and to strains of invasive isolates from adult patients. Data in this study documented the high rate of penicillin or multidrug resistance among isolates of pneumococci carried nasally in children in Asia and the Middle East and showed that this is due to the spread of a few predominant clones in the region.