Antiangiogenic activity of PLGA-Lupeol implants for potential intravitreal applications

• Published in: Biomedicine & pharmacotherapy Vol. 92; pp. 394 - 402
• Main Authors: Soares, Daniel Crístian Ferreira, de Paula Oliveira, Diogo Coelho, Barcelos, Luciola Silva, Barbosa, Alan Sales, Vieira, Lorena Carla, Townsend, Danyelle M, Rubello, Domenico, de Barros, André Luis Branco, Duarte, Lucienir Pains, Silva-Cunha, Armando
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.08.2017
• Subjects: Angiogenesis Inhibitors - administration & dosage; Angiogenesis Inhibitors - isolation & purification; Animals; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - isolation & purification; Antiangiogenic activity; Chick Embryo; Chorioallantoic Membrane - blood supply; Chorioallantoic Membrane - drug effects; Chorioallantoic Membrane - metabolism; Dose-Response Relationship, Drug; Drug Implants; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Internal Medicine; Intravitreal assays; Intravitreal Injections; Lactic Acid - administration & dosage; Lupeol; Maytenus; Medical Education; Pentacyclic Triterpenes - administration & dosage; Pentacyclic Triterpenes - isolation & purification; Plant Extracts - administration & dosage; Plant Extracts - isolation & purification; Plant Stems; PLGA ocular implants; Polyglycolic Acid - administration & dosage; Polylactic Acid-Polyglycolic Acid Copolymer; Intravitreal assays; Lupeol; PLGA ocular implants; Antiangiogenic activity
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2017.05.093

Graphical abstract