Cardiomyocyte-Specific Deletion of the Vitamin D Receptor Gene Results in Cardiac Hypertrophy

• Published in: Circulation (New York, N.Y.) Vol. 124; no. 17; pp. 1838 - 1847
• Main Authors: Chen, Songcang, Law, Christopher S., Grigsby, Christopher L., Olsen, Keith, Hong, Ting-Ting, Zhang, Yan, Yeghiazarians, Yerem, Gardner, David G.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 25.10.2011
• Subjects: Animals; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiomegaly - etiology; Cardiomegaly - genetics; Cardiomegaly - metabolism; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Gene Deletion; Gene Targeting; Heart; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Medical sciences; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Receptors, Calcitriol - deficiency; Receptors, Calcitriol - genetics; Agonist; Isoprenaline; Bronchodilator; β2-Adrenergic receptor; β-Adrenergic receptor agonist; Cardiovascular disease; isoproterenol; β-Adrenergic receptor; gene deletion; Vitamin D; Deletion; vitamin D receptor; cardiac hypertrophy

A variety of studies carried out using either human subjects or laboratory animals suggest that vitamin D and its analogues possess important beneficial activity in the cardiovascular system. Using Cre-Lox technology we have selectively deleted the vitamin D receptor (VDR) gene in the cardiac myocyt...