Early cortical signals in visual stimulus detection

• Published in: NeuroImage (Orlando, Fla.) Vol. 244; p. 118608
• Main Authors: Kwon, Hunki, Kronemer, Sharif I., Christison-Lagay, Kate L., Khalaf, Aya, Li, Jiajia, Ding, Julia Z, Freedman, Noah C, Blumenfeld, Hal
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2021; Elsevier Limited; Elsevier
• Subjects: Adolescent; Adult; Brain; Brain research; Broadband gamma; Cerebral Cortex; Cognition; Consciousness; Cortex (frontal); Cortex (temporal); Detection; Electrodes; Electroencephalography; Epilepsy; Epilepsy - physiopathology; Female; Frontal gyrus; Frontal Lobe - physiology; Hemispheric laterality; Humans; Information processing; Intracranial EEG; Language; Male; Memory; Mental Recall; Mental task performance; Middle Aged; Signal processing; Temporal Lobe - physiology; Transcranial magnetic stimulation; Visual cortex; Visual Cortex - physiology; Visual perception; Visual Perception - physiology; Visual stimuli; Young Adult; Intracranial EEG; Broadband gamma; Consciousness; Detection; Visual perception
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2021.118608

During visual conscious perception, the earliest responses linked to signal detection are little known. The current study aims to reveal the cortical neural activity changes in the earliest stages of conscious perception using recordings from intracranial electrodes. Epilepsy patients (N=158) were recruited from a multi-center collaboration and completed a visual word recall task. Broadband gamma activity (40–115Hz) was extracted with a band-pass filter and gamma power was calculated across subjects on a common brain surface. Our results show early gamma power increases within 0-50ms after stimulus onset in bilateral visual processing cortex, right frontal cortex (frontal eye fields, ventral medial/frontopolar, orbital frontal) and bilateral medial temporal cortex regardless of whether the word was later recalled. At the same early times, decreases were seen in the left rostral middle frontal gyrus. At later times after stimulus onset, gamma power changes developed in multiple cortical regions. These included sustained changes in visual and other association cortical networks, and transient decreases in the default mode network most prominently at 300–650ms. In agreement with prior work in this verbal memory task, we also saw greater increases in visual and medial temporal regions as well as prominent later (> 300ms) increases in left hemisphere language areas for recalled versus not recalled stimuli. These results suggest an early signal detection network in the frontal, medial temporal, and visual cortex is engaged at the earliest stages of conscious visual perception.