Gastrointestinal Complications of Obesity

Abstract Obesity is usually associated with morbidity related to diabetes mellitus and cardiovascular diseases. However, there are many gastrointestinal and hepatic diseases for which obesity is the direct cause [e.g. non-alcoholic fatty liver diseases (NAFLD)] or is a significant risk factor, such...

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Published inGastroenterology (New York, N.Y. 1943) Vol. 152; no. 7; pp. 1656 - 1670
Main Authors Camilleri, Michael, M.D, Malhi, Harmeet, M.B.B.S, Acosta, Andres, M.D., Ph.D
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2017
Subjects
Cancer
Esophageal Diseases - epidemiology
Esophageal Diseases - etiology
Fat
Gallbladder
Gastroenterology and Hepatology
Humans
Intestinal Diseases - epidemiology
Intestinal Diseases - etiology
Liver
Liver Diseases - epidemiology
Liver Diseases - etiology
Obesity - complications
Pancreas
Pancreatic Diseases - epidemiology
Pancreatic Diseases - etiology
Prevalence
Risk Factors
Stomach Diseases - epidemiology
Stomach Diseases - etiology
fat
cancer
gallbladder
liver
pancreas
RR
NAFLD
OR
Liver
CI
HCC
NASH
GERD
Fat
Gallbladder
LES
Pancreas
Cancer
BMI
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Summary:Abstract Obesity is usually associated with morbidity related to diabetes mellitus and cardiovascular diseases. However, there are many gastrointestinal and hepatic diseases for which obesity is the direct cause [e.g. non-alcoholic fatty liver diseases (NAFLD)] or is a significant risk factor, such as reflux esophagitis and gallstones. When obesity is a risk factor, it may interact with other mechanisms and result in earlier presentation or complicated diseases. There are increased odds ratios or relative risks of several gastrointestinal complications of obesity: gastroesophageal reflux disease (GERD), erosive esophagitis, Barrett’s esophagus, esophageal adenocarcinoma, erosive gastritis, gastric cancer, diarrhea, colonic diverticular disease, polyps, cancer, liver disease including NAFLD, cirrhosis, hepatocellular carcinoma, gallstones, acute pancreatitis, and pancreatic cancer. Gastroenterologists are uniquely poised to participate in the multidisciplinary management of obesity as physicians caring for people with obesity-related diseases, in addition to their expertise in nutrition and endoscopic interventions.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0016-5085
1528-0012
DOI:10.1053/j.gastro.2016.12.052