Hyperthermia for locally advanced breast cancer

Hyperthermia (HT) has a proven benefit for treating superficial malignancies, particularly chest wall recurrences of breast cancer. There has been less research utilising HT in patients with locally advanced breast cancer (LABC), but available data are promising. HT has been combined with chemothera...

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Published inInternational journal of hyperthermia Vol. 26; no. 7; pp. 618 - 624
Main Authors Zagar, Timothy M., Oleson, James R., Vujaskovic, Zeljko, Dewhirst, Mark W., Craciunescu, Oana I., Blackwell, Kimberly L., Prosnitz, Leonard R., Jones, Ellen L.
Format Journal Article
LanguageEnglish
Published England Informa UK, Ltd 01.10.2010
Taylor & Francis
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Abstract Hyperthermia (HT) has a proven benefit for treating superficial malignancies, particularly chest wall recurrences of breast cancer. There has been less research utilising HT in patients with locally advanced breast cancer (LABC), but available data are promising. HT has been combined with chemotherapy and/or radiotherapy in the neoadjuvant, definitive and adjuvant setting, albeit in series with small numbers of patients. There is only one phase III trial that examines hyperthermia in LABC, also with relatively small numbers of patients. The goal of this review is to highlight important research utilising HT in patients with LABC as well as to suggest future directions for its use.
AbstractList Hyperthermia (HT) has a proven benefit for treating superficial malignancies, particularly chest wall recurrences of breast cancer. There has been less research utilising HT in patients with locally advanced breast cancer (LABC), but available data are promising. HT has been combined with chemotherapy and/or radiotherapy in the neoadjuvant, definitive and adjuvant setting, albeit in series with small numbers of patients. There is only one phase III trial that examines hyperthermia in LABC, also with relatively small numbers of patients. The goal of this review is to highlight important research utilising HT in patients with LABC as well as to suggest future directions for its use.
Author Oleson, James R.
Blackwell, Kimberly L.
Prosnitz, Leonard R.
Vujaskovic, Zeljko
Craciunescu, Oana I.
Dewhirst, Mark W.
Jones, Ellen L.
Zagar, Timothy M.
AuthorAffiliation 3 Department of Radiation Oncology, University of North Carolina Cancer Hospital, Chapel Hill, North Carolina, USA
2 Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, North Carolina
1 Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina
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– name: 1 Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina
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Snippet Hyperthermia (HT) has a proven benefit for treating superficial malignancies, particularly chest wall recurrences of breast cancer. There has been less...
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SubjectTerms Breast Neoplasms - drug therapy
Breast Neoplasms - radiotherapy
Breast Neoplasms - therapy
Combined Modality Therapy
Female
Humans
hyperthermia
Hyperthermia, Induced
locally advanced breast cancer
radiation
Title Hyperthermia for locally advanced breast cancer
URI https://www.tandfonline.com/doi/abs/10.3109/02656736.2010.501051
https://www.ncbi.nlm.nih.gov/pubmed/20849257
https://search.proquest.com/docview/755171816
https://pubmed.ncbi.nlm.nih.gov/PMC2949291
Volume 26
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