Recent Advances in Dielectrophoretic Manipulation and Separation of Microparticles and Biological Cells

Dielectrophoresis (DEP) is an advanced microfluidic manipulation technique that is based on the interaction of polarized particles with the spatial gradient of a non-uniform electric field to achieve non-contact and highly selective manipulation of particles. In recent years, DEP has made remarkable...

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Published inBiosensors (Basel) Vol. 14; no. 9; p. 417
Main Authors Yao, Junzhu, Zhao, Kai, Lou, Jia, Zhang, Kaihuan
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 27.08.2024
MDPI
Subjects
Alternating current
cell separation
Cell Separation - methods
Cells
Cytoplasm
Dielectric properties
Dielectrophoresis
Direct current
Electric contacts
Electric fields
Electrophoresis
Fluids
Humans
integrated
Magnetic fields
Microfluidic Analytical Techniques
Microfluidics
microparticle manipulation
Microparticles
Radiation
Review
Separation
microparticle manipulation
cell separation
dielectrophoresis
microfluidics
integrated
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Summary:Dielectrophoresis (DEP) is an advanced microfluidic manipulation technique that is based on the interaction of polarized particles with the spatial gradient of a non-uniform electric field to achieve non-contact and highly selective manipulation of particles. In recent years, DEP has made remarkable progress in the field of microfluidics, and it has gradually transitioned from laboratory-scale research to high-throughput manipulation in practical applications. This paper reviews the recent advances in dielectric manipulation and separation of microparticles and biological cells and discusses in detail the design of chip structures for the two main methods, direct current dielectrophoresis (DC-DEP) and alternating current dielectrophoresis (AC-DEP). The working principles, technical implementation details, and other improved designs of electrode-based and insulator-based chips are summarized. Functional customization of DEP systems with specific capabilities, including separation, capture, purification, aggregation, and assembly of particles and cells, is then performed. The aim of this paper is to provide new ideas for the design of novel DEP micro/nano platforms with the desired high throughput for further development in practical applications.
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ISSN:2079-6374
2079-6374
DOI:10.3390/bios14090417