Adiponectin: Role in physiology and pathophysiology

Adiponectin, an adipokine secreted by adipocytes, is a well-known homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity through its anti-inflammatory, anti-fibrotic, and antioxidant effects. All these metabolic processes are mediated via two adiponectin receptor...

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Bibliographic Details
Published inInternational journal of preventive medicine Vol. 11; no. 1; p. 136
Main Author Diep Nguyen, ThiMong
Format Journal Article
LanguageEnglish
Published Mumbai Medknow Publications & Media Pvt. Ltd 01.01.2020
Wolters Kluwer - Medknow
Wolters Kluwer Medknow Publications
Subjects
adipokines
adiponectin
adipor
Insulin resistance
obesity
Pathophysiology
Physiology
Review
type 2 diabetes mellitus
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Summary:Adiponectin, an adipokine secreted by adipocytes, is a well-known homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity through its anti-inflammatory, anti-fibrotic, and antioxidant effects. All these metabolic processes are mediated via two adiponectin receptors, AdipoR1 and AdipoR2. In addition, adiponectin is one of the hormones with the highest plasma concentrations. Weight loss or caloric restriction leads to increasing adiponectin levels, and this increase is associated with increased insulin sensitivity. Therefore, the adiponectin pathway can play a crucial role in the development of drugs to treat type 2 diabetes mellitus and other obesity-related diseases affected by insulin resistance like cancers or cardiovascular diseases. Adiponectin appears to increase insulin sensitivity by improving glucose and lipid metabolisms. The objective of this review is to analyze current knowledge concerning adiponectin and, in particular, its role in physiology and pathophysiology.
Bibliography:ObjectType-Article-2
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ISSN:2008-7802
2008-8213
DOI:10.4103/ijpvm.IJPVM_193_20