Memantine decreases hippocampal glutamate levels: A magnetic resonance spectroscopy study

Glutamate (Glu) is associated with excitotoxic cell damage. Memantine modulates the glutamate induced excitotoxicity in Alzheimer's disease (AD). No information is available as to the influence of memantine on in vivo brain glutamate levels. Hippocampal Glu levels were measured in cognitively i...

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Published inProgress in neuro-psychopharmacology & biological psychiatry Vol. 32; no. 4; pp. 1005 - 1012
Main Authors Glodzik, Lidia, King, Kevin G., Gonen, Oded, Liu, Songtao, De Santi, Susan, de Leon, Mony J.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 15.05.2008
Elsevier
Subjects
AD
FOV
Cr
NAA
Glu
MCI
CSF
GDS
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Summary:Glutamate (Glu) is associated with excitotoxic cell damage. Memantine modulates the glutamate induced excitotoxicity in Alzheimer's disease (AD). No information is available as to the influence of memantine on in vivo brain glutamate levels. Hippocampal Glu levels were measured in cognitively impaired and normal individuals ( n = 10) before and after 6 months of memantine treatment, using three dimensional high spatial resolution (0.5 cm 3 voxels) proton magnetic resonance spectroscopy at 3 T. These measurements were also repeated in a non-treated cognitively normal group ( n = 6). Treatment with memantine decreased Glu/Cr (creatine) ratio in the left hippocampal region. Memantine reduced hippocampal glutamate levels, which may be consistent with its anti-excitotoxic property.
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ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2008.01.016