Advanced Proteomics as a Powerful Tool for Studying Toxins of Human Bacterial Pathogens

Exotoxins contribute to the infectious processes of many bacterial pathogens, mainly by causing host tissue damages. The production of exotoxins varies according to the bacterial species. Recent advances in proteomics revealed that pathogenic bacteria are capable of simultaneously producing more tha...

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Bibliographic Details
Published inToxins Vol. 11; no. 10; p. 576
Main Authors Duport, Catherine, Alpha-Bazin, Béatrice, Armengaud, And Jean
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 04.10.2019
MDPI
Subjects
b. cereus
Bacteria
bacterial toxins
Chemical and Process Engineering
E coli
Engineering Sciences
Environmental conditions
Enzymes
Exotoxins
Food engineering
Genomics
Gram-negative bacteria
Homeostasis
human pathogens
Life Sciences
Molecular biology
Pathogenesis
Pathogens
Post-transcription
Proteins
Proteomics
Review
Signal transduction
Toxins
Whooping cough
B. cereus
proteomics
bacterial toxins
human pathogens
Bacterial toxins
Human pathogens
Proteomics
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Summary:Exotoxins contribute to the infectious processes of many bacterial pathogens, mainly by causing host tissue damages. The production of exotoxins varies according to the bacterial species. Recent advances in proteomics revealed that pathogenic bacteria are capable of simultaneously producing more than a dozen exotoxins. Interestingly, these toxins may be subject to post-transcriptional modifications in response to environmental conditions. In this review, we give an outline of different bacterial exotoxins and their mechanism of action. We also report how proteomics contributed to immense progress in the study of toxinogenic potential of pathogenic bacteria over the last two decades.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2072-6651
2072-6651
DOI:10.3390/toxins11100576