SARS-CoV-2 Interference of Influenza Virus Replication in Syrian Hamsters

• Published in: The Journal of infectious diseases Vol. 225; no. 2; pp. 282 - 286
• Main Authors: Halfmann, Peter J, Nakajima, Noriko, Sato, Yuko, Takahashi, Kenta, Accola, Molly, Chiba, Shiho, Fan, Shufang, Neumann, Gabriele, Rehrauer, William, Suzuki, Tadaki, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 18.01.2022
• Subjects: Animals; Antiviral drugs; Coinfection; COVID-19; Cricetinae; Humans; Influenza; Influenza A Virus, H3N2 Subtype; Major and Brief Reports; Mesocricetus; Myxovirus Resistance Proteins - metabolism; Nose; Rodents; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Virus Replication; Viruses; SARS-CoV-2; Coinfection; Influenza; antiviral; MX1

Abstract In hamsters, SARS-CoV-2 infection at the same time as or before H3N2 influenza virus infection resulted in significantly reduced influenza virus titers in the lungs and nasal turbinates. This interference may be correlated with SARS-CoV-2–induced expression of MX1. In hamsters, a previous i...