SARS-CoV-2 Interference of Influenza Virus Replication in Syrian Hamsters

Abstract In hamsters, SARS-CoV-2 infection at the same time as or before H3N2 influenza virus infection resulted in significantly reduced influenza virus titers in the lungs and nasal turbinates. This interference may be correlated with SARS-CoV-2–induced expression of MX1. In hamsters, a previous i...

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Published inThe Journal of infectious diseases Vol. 225; no. 2; pp. 282 - 286
Main Authors Halfmann, Peter J, Nakajima, Noriko, Sato, Yuko, Takahashi, Kenta, Accola, Molly, Chiba, Shiho, Fan, Shufang, Neumann, Gabriele, Rehrauer, William, Suzuki, Tadaki, Kawaoka, Yoshihiro
Format Journal Article
LanguageEnglish
Published US Oxford University Press 18.01.2022
Subjects
Animals
Antiviral drugs
Coinfection
COVID-19
Cricetinae
Humans
Influenza
Influenza A Virus, H3N2 Subtype
Major and Brief Reports
Mesocricetus
Myxovirus Resistance Proteins - metabolism
Nose
Rodents
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Virus Replication
Viruses
SARS-CoV-2
Coinfection
Influenza
antiviral
MX1
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Summary:Abstract In hamsters, SARS-CoV-2 infection at the same time as or before H3N2 influenza virus infection resulted in significantly reduced influenza virus titers in the lungs and nasal turbinates. This interference may be correlated with SARS-CoV-2–induced expression of MX1. In hamsters, a previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interferes with a sequential infection with influenza virus (H3N2 subtype). The induction of the interferon-stimulated gene MX1induced by SARS-CoV-2 infection may play a partial role in the interference with this influenza subtype.
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ISSN:0022-1899
1537-6613
1537-6613
DOI:10.1093/infdis/jiab587