SARS-CoV-2 Interference of Influenza Virus Replication in Syrian Hamsters

Abstract In hamsters, SARS-CoV-2 infection at the same time as or before H3N2 influenza virus infection resulted in significantly reduced influenza virus titers in the lungs and nasal turbinates. This interference may be correlated with SARS-CoV-2–induced expression of MX1. In hamsters, a previous i...

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Published inThe Journal of infectious diseases Vol. 225; no. 2; pp. 282 - 286
Main Authors Halfmann, Peter J, Nakajima, Noriko, Sato, Yuko, Takahashi, Kenta, Accola, Molly, Chiba, Shiho, Fan, Shufang, Neumann, Gabriele, Rehrauer, William, Suzuki, Tadaki, Kawaoka, Yoshihiro
Format Journal Article
LanguageEnglish
Published US Oxford University Press 18.01.2022
Subjects
Animals
Antiviral drugs
Coinfection
COVID-19
Cricetinae
Humans
Influenza
Influenza A Virus, H3N2 Subtype
Major and Brief Reports
Mesocricetus
Myxovirus Resistance Proteins - metabolism
Nose
Rodents
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Virus Replication
Viruses
SARS-CoV-2
Coinfection
Influenza
antiviral
MX1
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Abstract Abstract In hamsters, SARS-CoV-2 infection at the same time as or before H3N2 influenza virus infection resulted in significantly reduced influenza virus titers in the lungs and nasal turbinates. This interference may be correlated with SARS-CoV-2–induced expression of MX1. In hamsters, a previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interferes with a sequential infection with influenza virus (H3N2 subtype). The induction of the interferon-stimulated gene MX1induced by SARS-CoV-2 infection may play a partial role in the interference with this influenza subtype.
AbstractList In hamsters, SARS-CoV-2 infection at the same time as or before H3N2 influenza virus infection resulted in significantly reduced influenza virus titers in the lungs and nasal turbinates. This interference may be correlated with SARS-CoV-2–induced expression of MX1.
In hamsters, SARS-CoV-2 infection at the same time as or before H3N2 influenza virus infection resulted in significantly reduced influenza virus titers in the lungs and nasal turbinates. This interference may be correlated with SARS-CoV-2-induced expression of MX1.In hamsters, SARS-CoV-2 infection at the same time as or before H3N2 influenza virus infection resulted in significantly reduced influenza virus titers in the lungs and nasal turbinates. This interference may be correlated with SARS-CoV-2-induced expression of MX1.
Abstract In hamsters, SARS-CoV-2 infection at the same time as or before H3N2 influenza virus infection resulted in significantly reduced influenza virus titers in the lungs and nasal turbinates. This interference may be correlated with SARS-CoV-2–induced expression of MX1. In hamsters, a previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interferes with a sequential infection with influenza virus (H3N2 subtype). The induction of the interferon-stimulated gene MX1induced by SARS-CoV-2 infection may play a partial role in the interference with this influenza subtype.
In hamsters, SARS-CoV-2 infection at the same time as or before H3N2 influenza virus infection resulted in significantly reduced influenza virus titers in the lungs and nasal turbinates. This interference may be correlated with SARS-CoV-2–induced expression of MX1 . In hamsters, a previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interferes with a sequential infection with influenza virus (H3N2 subtype). The induction of the interferon-stimulated gene MX1 induced by SARS-CoV-2 infection may play a partial role in the interference with this influenza subtype.
Author Accola, Molly
Sato, Yuko
Suzuki, Tadaki
Kawaoka, Yoshihiro
Halfmann, Peter J
Neumann, Gabriele
Rehrauer, William
Takahashi, Kenta
Fan, Shufang
Chiba, Shiho
Nakajima, Noriko
AuthorAffiliation 4 Department of Pathology and Laboratory Medicine, University of Wisconsin–Madison , Madison, Wisconsin , USA
3 UW Health Clinical Laboratories, University of Wisconsin Hospital and Clinics , Madison, Wisconsin , USA
2 Department of Pathology, National Institute of Infectious Diseases , Tokyo , Japan
1 Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin–Madison , Madison, Wisconsin , USA
5 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo , Tokyo , Japan
AuthorAffiliation_xml – name: 1 Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin–Madison , Madison, Wisconsin , USA
– name: 2 Department of Pathology, National Institute of Infectious Diseases , Tokyo , Japan
– name: 5 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo , Tokyo , Japan
– name: 3 UW Health Clinical Laboratories, University of Wisconsin Hospital and Clinics , Madison, Wisconsin , USA
– name: 4 Department of Pathology and Laboratory Medicine, University of Wisconsin–Madison , Madison, Wisconsin , USA
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  givenname: Gabriele
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ContentType Journal Article
Copyright The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2021
The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
Copyright_xml – notice: The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2021
– notice: The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
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Keywords SARS-CoV-2
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Influenza
antiviral
MX1
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Snippet Abstract In hamsters, SARS-CoV-2 infection at the same time as or before H3N2 influenza virus infection resulted in significantly reduced influenza virus...
In hamsters, SARS-CoV-2 infection at the same time as or before H3N2 influenza virus infection resulted in significantly reduced influenza virus titers in the...
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SubjectTerms Animals
Antiviral drugs
Coinfection
COVID-19
Cricetinae
Humans
Influenza
Influenza A Virus, H3N2 Subtype
Major and Brief Reports
Mesocricetus
Myxovirus Resistance Proteins - metabolism
Nose
Rodents
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Virus Replication
Viruses
Title SARS-CoV-2 Interference of Influenza Virus Replication in Syrian Hamsters
URI https://www.ncbi.nlm.nih.gov/pubmed/34875072
https://www.proquest.com/docview/2626194517
https://www.proquest.com/docview/2608131799
https://pubmed.ncbi.nlm.nih.gov/PMC8689717
Volume 225
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