Holy Basil leaf extract decreases tumorigenicity and metastasis of aggressive human pancreatic cancer cells in vitro and in vivo: Potential role in therapy

Highlights • Extracts from Ocimum sanctum (“Holy Basil”) leaves inhibit the proliferation, motility and invasive capability of PC cells. • Aqueous extracts of O. sanctum leaves decrease the tumorigenicity of orthotopic transplanted PC cells. • Components present in O. sanctum leaves have promising c...

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Bibliographic Details
Published inCancer letters Vol. 336; no. 2; pp. 270 - 280
Main Authors Shimizu, Tomohiro, Torres, María P, Chakraborty, Subhankar, Souchek, Joshua J, Rachagani, Satyanarayana, Kaur, Sukhwinder, Macha, Muzafar, Ganti, Apar K, Hauke, Ralph J, Batra, Surinder K
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 19.08.2013
Subjects
Animals
Apoptosis
Apoptosis - drug effects
Basil
Carcinogenesis - drug effects
Cell Survival - drug effects
Female
Hematology, Oncology and Palliative Medicine
Humans
Mice
Mice, Nude
Neoplasm Metastasis
Ocimum - chemistry
Pancreatic cancer
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - pathology
Plant Extracts - pharmacology
Plant Leaves - chemistry
Prognosis
Therapy
Tumorigenicity
Xenograft Model Antitumor Assays
Basil
Therapy
Tumorigenicity
Pancreatic cancer
Apoptosis
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Summary:Highlights • Extracts from Ocimum sanctum (“Holy Basil”) leaves inhibit the proliferation, motility and invasive capability of PC cells. • Aqueous extracts of O. sanctum leaves decrease the tumorigenicity of orthotopic transplanted PC cells. • Components present in O. sanctum leaves have promising characteristics for PC therapy.
Bibliography:These authors contributed equally to the work
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.03.017