Reliable mite-specific IgE testing in nasal secretions by means of allergen microarray

• Published in: Journal of allergy and clinical immunology Vol. 140; no. 1; pp. 301 - 303.e8
• Main Authors: Berings, Margot, MD, Arasi, Stefania, MD, De Ruyck, Natalie, MSc, Perna, Serena, MSc, Resch, Yvonne, PhD, Lupinek, Christian, MD, Chen, Kuan-Wei, PhD, Vrtala, Susanne, PhD, Pajno, Giovanni Battista, MD, Bachert, Claus, MD, PhD, Lambrecht, Bart N., MD, PhD, Dullaers, Melissa, PhD, Valenta, Rudolf, MD, Matricardi, Paolo Maria, MD, Gevaert, Philippe, MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 01.07.2017
• Subjects: Allergens; Allergies; Allergy and Immunology; Enzymes; Immunoassay; Immunoglobulin E; Medicin och hälsovetenskap; Mites; Nose; Otolaryngology; Secretions; Silicon germanides; Sweden
• ISSN: 0091-6749; 1097-6825; 1097-6825
• DOI: 10.1016/j.jaci.2016.11.047

[...]HDM sIgE in NasSec predicted with 100% specificity, but poor sensitivity (FDs, 70%; SPs, 73%) the results in serum. The results of the first test were generally reproduced in the second test. [...]this time, the prevalence of sIgE to group 1 molecules in serum and NasSec was more similar (serum, 77%; NasSec, 62%-77%; see Tables E5 and E6 in this article's Online Repository at www.jacionline.org). [...]the microarray results in NasSec were very predictive for the serum results. [...]testing nasal IgE to allergen molecules by a microarray approach may soon become a noninvasive alternative in the diagnostic workup of AR.