ECMO for bridging lung transplantation

• Published in: European journal of medical research Vol. 29; no. 1; pp. 628 - 9
• Main Authors: Zhang, Chuhan, Wang, Qingjing, Lu, Anwei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.12.2024; BioMed Central; BMC
• Subjects: Analysis; Bivalirudin; ECMO; ECMO bridging lung transplantation; Extracorporeal Membrane Oxygenation - methods; Humans; Lung allocation score; Lung transplantation; Lung Transplantation - methods; Review; Transplantation of organs, tissues, etc; ECMO; Lung allocation score; Lung transplantation; ECMO bridging lung transplantation
• ISSN: 2047-783X; 0949-2321; 2047-783X
• DOI: 10.1186/s40001-024-02239-y

With the shift in donor lung allocation from blood type and waiting order to the use of the lung allocation score (LAS) system, there are increasingly more cases of ECMO bridging lung transplantation. However, there are still some problems in case selection, implementation, and management. We analyzed and summarized a series of data on ECMO bridging lung transplantation through an extensive literature review. The improvement of the lung transplant allocation system and the progress of ECMO technology have made the ECMO bridge to lung transplant more widely used in clinical practice. The selection of bridge patients is a crucial link in the success of transplantation, and accurate assessment of the patient before transplantation is necessary. The advantages and disadvantages of different bridge strategies exist, and the appropriate bridge strategy should be selected based on the patient's situation. Bleeding and thrombosis complications often occur during ECMO circulation, and there is currently no optimal anticoagulation strategy. The predictive score for bridge post-outcome is still subject to certain limitations. ECMO bridging lung transplantation is suitable for patients waiting for lung transplantation when other respiratory support is ineffective or when hemodynamic instability occurs the disease is severe and the donor organ is easily obtainable. Patients aged 65 years or older, or have reversible multiple organ dysfunction should not be included as contraindications for ECMO bridging lung transplantation.