Ionophoretic activities of oligopeptide lactones and resin-glycosides in human erythrocytes

Oligopeptide lactones (theonellapeptolides) isolated from the Okinawan marine sponge Theonella swinhoei and resin-glycosides (merremosides) from the tuber of an Indonesian medicinal plant Merremia mammosa were examined regarding their activities in transporting Na+, K+, and Ca++ ions into human eryt...

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Published inChemical & pharmaceutical bulletin Vol. 37; no. 6; pp. 1679 - 1681
Main Authors KITAGAWA, I, OHASHI, K, KAWANISHI, H, SHIBUYA, H, SHINKAI, K, AKEDO, H
Format Journal Article
LanguageEnglish
Published Tokyo Maruzen 1989
Subjects
Biological and medical sciences
Erythrocytes - analysis
General pharmacology
Glycosides - blood
Humans
In Vitro Techniques
Iontophoresis
Lactones - blood
Medical sciences
Oligopeptides - blood
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Resins, Plant
Human
Oligopeptides
Japan
Glucoside
Red blood cell
Animal origin
Ion transport
Lactone
In vitro
Medicinal plant
Marine environment
Asia
Porifera
Membrane transport
Ionophore
Invertebrata
Comparative study
Indonesia
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Summary:Oligopeptide lactones (theonellapeptolides) isolated from the Okinawan marine sponge Theonella swinhoei and resin-glycosides (merremosides) from the tuber of an Indonesian medicinal plant Merremia mammosa were examined regarding their activities in transporting Na+, K+, and Ca++ ions into human erythrocytes. Each of these lactones, which had been shown, using a supported liquid membrane, to have an ionophoretic effect on the alkali metal ions, transported the ions to a different extent. The ion transporting activities of these compounds were completely lost when the macrocyclic lactone structures were cleaved by sodium methylate. Resin-glycosides with an additional branched glycosyl residue showed much greater ion transporting activities than those without it.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.37.1679