A phenomenological model of whole brain dynamics using a network of neural oscillators with power-coupling

• Published in: Scientific reports Vol. 13; no. 1; p. 16935
• Main Authors: Bandyopadhyay, Anirban, Ghosh, Sayan, Biswas, Dipayan, Chakravarthy, V. Srinivasa, S. Bapi, Raju
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.10.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/378; 639/705; Correlation coefficient; Humanities and Social Sciences; multidisciplinary; Neural networks; Neuroimaging; Oscillators; Science; Science (multidisciplinary); Structure-function relationships; Training
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-43547-3

We present a general, trainable oscillatory neural network as a large-scale model of brain dynamics. The model has a cascade of two stages - an oscillatory stage and a complex-valued feedforward stage - for modelling the relationship between structural connectivity and functional connectivity from neuroimaging data under resting brain conditions. Earlier works of large-scale brain dynamics that used Hopf oscillators used linear coupling of oscillators. A distinctive feature of the proposed model employs a novel form of coupling known as power coupling. Oscillatory networks based on power coupling can accurately model arbitrary multi-dimensional signals. Training the lateral connections in the oscillator layer is done by a modified form of Hebbian learning, whereas a variation of the complex backpropagation algorithm does training in the second stage. The proposed model can not only model the empirical functional connectivity with remarkable accuracy (correlation coefficient between simulated and empirical functional connectivity- 0.99) but also identify default mode network regions. In addition, we also inspected how structural loss in the brain can cause significant aberration in simulated functional connectivity and functional connectivity dynamics; and how it can be restored with optimized model parameters by an in silico perturbational study.