Structure-activity correlation of flavonoids for inhibition of bovine lens aldose reductase

To clarify the structure-activity correlation of flavonoids for inhibition of aldose reductase, about fifty flavonoid compounds were screened. The presence of hydrophobic substituents on the A ring and hydrophilic substituents on the B ring of the flavonoid skeleton was suggested to improve the pote...

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Published inChemical & pharmaceutical bulletin Vol. 37; no. 7; pp. 1813 - 1815
Main Authors IINUMA, M, TANAKA, T, MIZUNO, M, KATSUZAKI, T, OGAWA, H
Format Journal Article
LanguageEnglish
Published Tokyo Maruzen 1989
Subjects
Aldehyde Reductase - antagonists & inhibitors
Animals
Biological and medical sciences
Cattle
Digestive system
Flavonoids - pharmacology
Lens, Crystalline - enzymology
Medical sciences
Pharmacology. Drug treatments
Structure-Activity Relationship
Sugar Alcohol Dehydrogenases - antagonists & inhibitors
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Summary:To clarify the structure-activity correlation of flavonoids for inhibition of aldose reductase, about fifty flavonoid compounds were screened. The presence of hydrophobic substituents on the A ring and hydrophilic substituents on the B ring of the flavonoid skeleton was suggested to improve the potency of inhibitory activity. The activities of extracts of Scutellaria baicalensis, Andrographis paniculata and Gutierrezia microcephala are also described.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.37.1813