Hyperuricemia remission after colorectal cancer surgery for colorectal cancer patients

• Published in: Scientific reports Vol. 13; no. 1; p. 18867
• Main Authors: Liu, Fei, Huang, Yin, Li, Zi-Wei, Liu, Xu-Rui, Liu, Xiao-Yu, Lv, Quan, Shu, Xin-Peng, Li, Lian-Shuo, Zhang, Wei, Tong, Yue, Zeng, Meng-Hua, Peng, Dong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67; 692/499; Body mass index; Cancer; Colorectal cancer; Colorectal carcinoma; Humanities and Social Sciences; Hyperuricemia; multidisciplinary; Patients; Regression analysis; Remission; Remission (Medicine); Science; Science (multidisciplinary); Surgery; Tumors; Uric acid
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-46348-w

The purpose of this study was to investigate whether patients with colorectal cancer (CRC) combined with hyperuricemia remitted 1 year after CRC surgery. CRC patients combined with hyperuricemia who underwent radical surgery were included from a single clinical center from Jan 2016 to Dec 2021. Baseline characteristics was compared between the remission group and the non-remission group. Multivariate logistic regression was used to find the possible predictive factors of hyperuricemia remission. A total of 91 patients were included for data analysis, retrospectively. There were 34 (37.4%) patients in the remission group and 57 (62.6%) patients in the non-remission group. The mean preoperative weight and body mass index (BMI) were 61.2 ± 10.7 (kg) and 24.1 ± 3.3 (kg/m 2 ). 21 (23.1%) patients had a history of drinking. We found that the weight and BMI were not significantly different before and 1 year after CRC surgery ( P  > 0.05). In contrast, uric acid values were significantly decreased ( P  < 0.01). Meanwhile, the outcomes showed there were no significant differences in the baseline characteristics between the remission and non-remission groups ( P  > 0.05). According to multivariate logistic regression, we found that the history of drinking was a predictive factor of hyperuricemia remission (OR = 0.046, 95% CI 0.005–0.475, P  = 0.010). CRC patients with hyperuricemia had a 37.4% remission from hyperuricemia 1 year after CRC surgery. Tumor location, tumor stage, and tumor size did not predict the remission of hyperuricemia. Notably, the history of drinking was a predictive factor of hyperuricemia remission.