Edaravone promotes functional recovery after mechanical peripheral nerve injury

Edaravone has been shown to reduce ischemia/reperfusion-induced peripheral nerve injury. However, the therapeutic effect of edaravone on peripheral nerve injury caused by mechanical factors is unknown. In the present study, we established a peripheral nerve injury model by crushing the sciatic nerve...

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Published inNeural regeneration research Vol. 9; no. 18; pp. 1709 - 1715
Main Authors Zhang, Teng, Li, Zhengwei, Dong, Jianli, Nan, Feng, Li, Tao, Yu, Qing
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 15.09.2014
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Subjects
Apoptosis
Dosage and administration
Drug therapy
expression
Neuroprotective agents
Patient outcomes
Peripheral nerve diseases
Spinal cord
Technical Updates
依达拉奉
功能恢复
周围神经损伤
外周神经损伤
机械因素
缺血/再灌注
超氧化物歧化酶活性
China
Bcl-2
sciatic nerve injury
edaravone
mechanical injury
lipid peroxidation
neural regeneration
free radical damage
superoxide dismutase
Bax
nerve regeneration
peripheral nerve injury
malondialdehyde
NSFC grant
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Summary:Edaravone has been shown to reduce ischemia/reperfusion-induced peripheral nerve injury. However, the therapeutic effect of edaravone on peripheral nerve injury caused by mechanical factors is unknown. In the present study, we established a peripheral nerve injury model by crushing the sciatic nerve using hemostatic forceps, and then administered edaravone 3 mg/kg intraperitoneally. The sciatic functional index and superoxide dismutase activity of the sciatic nerve were increased, and the malondialdehyde level was decreased in animals in the edaravone group compared with those in the model group. Bcl-2 expression was increased, but Bax expres- sion was decreased in anterior horn cells of the L4-6 spinal cord segments. These results indicated that edaravone has a neuroprotective effect following peripheral nerve injury caused by mechan- ical factors through alleviating free radical damage to cells and inhibiting lipid peroxidation, as well as regulating apoptosis-related protein expression.
Bibliography:nerve regeneration; peripheral nerve injury; mechanical injury; sciatic nerve injury;edaravone; lipid peroxidation; free radical damage; malondialdehyde; superoxide dismutase; Bcl-2;Bax; NSFC grant; neural regeneration
Edaravone has been shown to reduce ischemia/reperfusion-induced peripheral nerve injury. However, the therapeutic effect of edaravone on peripheral nerve injury caused by mechanical factors is unknown. In the present study, we established a peripheral nerve injury model by crushing the sciatic nerve using hemostatic forceps, and then administered edaravone 3 mg/kg intraperitoneally. The sciatic functional index and superoxide dismutase activity of the sciatic nerve were increased, and the malondialdehyde level was decreased in animals in the edaravone group compared with those in the model group. Bcl-2 expression was increased, but Bax expres- sion was decreased in anterior horn cells of the L4-6 spinal cord segments. These results indicated that edaravone has a neuroprotective effect following peripheral nerve injury caused by mechan- ical factors through alleviating free radical damage to cells and inhibiting lipid peroxidation, as well as regulating apoptosis-related protein expression.
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Author contributions: All authors participated in the study design, conduction, and evaluation. Nan F and Zhang T drafted the manuscript. All authors approved the final version of the paper.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.141808