Distinct evolution of calcium channel antibody types in Lambert–Eaton myasthenic syndrome

Abstract To determine whether titers of anti-P/Q type and anti-N type calcium channel antibodies provide distinct information, both types of assay were performed during follow-up of 7 patients with Lambert–Eaton myasthenic syndrome (LEMS). In 4 patients with both antibody responses, titers evolved i...

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Bibliographic Details
Published inJournal of neuroimmunology Vol. 197; no. 1; pp. 47 - 53
Main Authors Martin-Moutot, Nicole, De Haro, Luc, Seagar, Michael
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.06.2008
Subjects
Aged
Allergy and Immunology
Autoantibodies - biosynthesis
Autoantibodies - blood
Autoantibodies - classification
Autoimmune diseases
Calcium channel
Calcium Channels, N-Type - immunology
Calcium Channels, P-Type - immunology
Calcium Channels, Q-Type - immunology
Carcinoma, Small Cell - diagnosis
Carcinoma, Small Cell - immunology
Carcinoma, Small Cell - therapy
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - immunology
Carcinoma, Squamous Cell - therapy
Evolution, Molecular
Female
Humans
Lambert-Eaton Myasthenic Syndrome - diagnosis
Lambert-Eaton Myasthenic Syndrome - immunology
Lambert-Eaton Myasthenic Syndrome - therapy
Lambert–Eaton myasthenic syndrome
Lung Neoplasms - diagnosis
Lung Neoplasms - immunology
Lung Neoplasms - therapy
Male
Middle Aged
Neurology
Neuromuscular diseases
Paraneoplastic syndromes
Neuromuscular diseases
Paraneoplastic syndromes
Autoimmune diseases
Calcium channel
Lambert–Eaton myasthenic syndrome
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Summary:Abstract To determine whether titers of anti-P/Q type and anti-N type calcium channel antibodies provide distinct information, both types of assay were performed during follow-up of 7 patients with Lambert–Eaton myasthenic syndrome (LEMS). In 4 patients with both antibody responses, titers evolved independently and often in an inverse relationship. Two patients with squamous cell lung carcinoma (SqCLC) produced anti-N type channel antibodies, but no detectable anti-P/Q channel responses. These results suggest that anti-N channel autoantibodies constitute an immune response distinct from the anti-P/Q type channel specificity and can also correlate with clinical evolution. Consequently combined assays may provide more comprehensive information during follow-up of LEMS.
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ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2008.04.001