On the cardiorespiratory coordination assessed by the photoplethysmography imaging technique

• Published in: Scientific reports Vol. 13; no. 1; p. 14645
• Main Authors: Borik, Stefan, Keller, Micha, Perlitz, Volker, Lyra, Simon, Pelz, Holger, Müller, Gero, Leonhardt, Steffen, Blazek, Vladimir
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.09.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/443/1338; 631/443/1784; 639/166/985; 639/624/1107/510; Ambient temperature; Biomedical engineering; Cold; Heart; Humanities and Social Sciences; Information technology; Investigations; Methods; multidisciplinary; Pain; Physiology; Respiration; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-41828-5

Cardiorespiratory coordination (CRC) probes the interaction between cardiac and respiratory oscillators in which cardiac and respiratory activity are synchronized, with individual heartbeats occurring at approximately the same temporal positions during several breathing cycles. An increase of CRC has previously been related to pathological stressful states. We studied CRC employing coordigrams computed from non-contact photoplethysmography imaging (PPGI) and respiratory data using the optical flow method. In a blocked study design, we applied the cold pressure test (CPT), water at ambient temperature (AWT), and intermittent resting conditions. In controls (no intervention), CRC remained on initial low levels throughout measurements. In the experimental group (AWT and CPT intervention), CRC decreased during AWT and CPT. Following both interventions, CRC increased significantly, with a rebound effect following AWT. In controls, HR increased steadily over time. CPT evoked a significant HR increase which correlated with subjective stress/pain ratings. The CRC increase following AWT correlated significantly with subjective pain ( r  = .79) and stress ( r  = .63) ratings. Furthermore, we observed a significant correlation ( r  = − .80) between mean RMSSD and mean duration of CRC, which further supports an association between autonomic state and CRC level. CRC analysis obtained from cutaneous tissue perfusion data therefore appears to be a sensitive and useful method for the study of CRC and ANS activity. Future studies need to investigate the physiological principles and clinical significance of these findings.