Natural history of perihematomal edema in patients with hyperacute spontaneous intracerebral hemorrhage

• Published in: Stroke (1970) Vol. 33; no. 11; pp. 2631 - 2635
• Main Authors: GEBEL, James M, JAUCH, Edward C, BROTT, Thomas G, KHOURY, Jane, SAUERBECK, Laura, SALISBURY, Shelia, SPILKER, Judith, TOMSICK, Thomas A, DULDNER, John, BRODERICK, Joseph P
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.11.2002; American Heart Association, Inc
• Subjects: Acute Disease; Biological and medical sciences; Brain Edema - complications; Brain Edema - diagnostic imaging; Cerebral Hemorrhage - complications; Cerebral Hemorrhage - diagnostic imaging; Disease Progression; Hematoma - complications; Hematoma - diagnostic imaging; Humans; Medical sciences; Neurology; Prospective Studies; Retrospective Studies; Time Factors; Tomography, X-Ray Computed; Vascular diseases and vascular malformations of the nervous system; Human; computed tomography; Nervous system diseases; Radiodiagnosis; Acute; Spontaneous; Cardiovascular disease; natural history; Cerebral disorder; Vascular disease; intracerebral hemorrhage; Cerebral hemorrhage; Central nervous system disease; Medical imagery; Evolution; Computerized axial tomography; Cerebral edema; Cerebrovascular disease
• ISSN: 0039-2499; 1524-4628
• DOI: 10.1161/01.STR.0000035284.12699.84

The natural history of perihematomal edema in human hyperacute spontaneous intracerebral hemorrhage (ICH) has not been well described. This study was a secondary analysis of a previously reported prospective, population-based study of hematoma growth in 142 patients with spontaneous ICH. Patients were first imaged within 3 hours of onset, then 1 and 20 hours later. We excluded patients with anticoagulant use (n=7), underlying aneurysm/vascular malformation (n=9), trauma (n=1), incomplete data (n=20), infratentorial ICH (n=17), and no consent (n=2), leaving an overall study population of 86 patients. From this overall group we further excluded patients with intraventricular extension (n=38), subsequent surgery (n=5), or death (n=2) before 20-hour postbaseline CT. This second, "restricted" analysis group of 41 patients was relatively devoid of clinical or radiological variables likely to confound edema measurement. Absolute and relative edema volumes (edema volume divided by hematoma volume) were descriptively summarized. Correlations between baseline edema volumes and relevant clinical and radiological variables were then performed. Overall, median absolute edema volume increased from 6.93 to 14.4 cm(3) during the first 24 hours after ICH, and median relative edema volume increased from 0.47 to 0.81. In the restricted group, median absolute edema volume was 7.4 cm(3) at baseline and 11.0 cm(3) at 24 hours after ICH, and median relative edema volume increased from 0.55 to 0.81. Baseline relative edema volume was significantly negatively correlated with subsequent change in relative edema volume from baseline to 20-hour CT (r=0.57, P=0.0002) but was not significantly correlated with other clinical and radiological variables, including hematoma volume or change in hematoma volume. Perihematomal edema volume increases by approximately 75% during the first 24 hours after hyperacute spontaneous ICH. Patients with the least amounts of baseline relative edema volume were most likely to develop significant additional amounts of edema during the first 24 hours after spontaneous ICH.